Erythromycin ameliorates renal injury via anti-inflammatory effects in experimental diabetic rats

被引:0
作者
A. Tone
K. Shikata
M. Sasaki
S. Ohga
K. Yozai
S. Nishishita
H. Usui
R. Nagase
D. Ogawa
S. Okada
Y. Shikata
J. Wada
H. Makino
机构
[1] Okayama University Graduate School of Medicine,Department of Medicine and Clinical Science
[2] Dentistry and Pharmaceutical Sciences,undefined
来源
Diabetologia | 2005年 / 48卷
关键词
Anti-inflammatory effect; Diabetic nephropathy; Erythromycin; ICAM-1; Inflammation; Macrolide; Macrophage; NF-κB; TGF-β; Type IV collagen;
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
页码:2402 / 2411
页数:9
相关论文
共 155 条
[1]  
Parving HH(2001)The effect of irbesartan on the development of diabetic nephropathy in patients with type 2 diabetes N Engl J Med 345 870-878
[2]  
Lehnert H(1993)The effect of angiotensin-converting-enzyme inhibition on diabetic nephropathy. The Collaborative Study Group N Engl J Med 329 1456-1462
[3]  
Brochner-Mortensen J(2001)Nitric oxide system is involved in glomerular hyperfiltration in Japanese normo- and micro-albuminuric patients with type 2 diabetes Diabetes Res Clin Pract 53 149-159
[4]  
Gomis R(1997)Characterization of protein kinase C beta isoform activation on the gene expression of transforming growth factor-beta, extracellular matrix components, and prostanoids in the glomeruli of diabetic rats J Clin Invest 100 115-126
[5]  
Andersen S(1997)Upregulation of mesangial growth factor and extracellular matrix synthesis by advanced glycation end products via a receptor-mediated mechanism Diabetes 46 1881-1887
[6]  
Arner P(1994)Advanced glycation end products up-regulate gene expression found in diabetic glomerular disease Proc Natl Acad Sci U S A 91 9436-9440
[7]  
Lewis EJ(1993)The role of macrophages in diabetic glomerulosclerosis Am J Kidney Dis 21 480-485
[8]  
Hunsicker LG(2000)Early glomerular macrophage recruitment in streptozotocin-induced diabetic rats Diabetes 49 466-475
[9]  
Bain RP(2004)Macrophages in mouse type 2 diabetic nephropathy: correlation with diabetic state and progressive renal injury Kidney Int 65 116-128
[10]  
Rohde RD(1998)Increased expression of selectins in kidneys of patients with diabetic nephropathy Diabetologia 41 185-192