Cervids ACE2 Residues that Bind the Spike Protein can Provide Susceptibility to SARS-CoV-2

被引：0
作者：
Luciano Rodrigo Lopes
机构：
[1] Universidade Federal de São Paulo – UNIFESP,Bioinformatics and Bio
来源：
EcoHealth | 2023年 / 20卷
关键词：
SARS-CoV-2; ACE2; Coronavirus; White-tailed deer; Cervids;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The susceptibility of the white-tailed deer (WTD; Odocoileus virginianus) to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has highlighted cervids as coronavirus reservoirs. This study aimed to evaluate the angiotensin-converting enzyme 2 (ACE2) residues which bind the spike protein of SARS-CoV-2 from 16 cervids to predict their potential susceptibility to SARS-CoV-2 infection. Eleven out of 16 species presented identical ACE2 key residues to WTD ACE2. Four cervids presented K31N, a variant associated with low SARS-CoV-2 susceptibility. Large herding of cervids with ACE2 key residues identical to that of the WTD can result in extensive reservoirs of SARS-CoV-2. Cervids as potential reservoirs could favor SARS-CoV-2 adaptation and the emergence of new coronavirus strains.
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页码：9 / 17
页数：8
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