Complexation of cyclodextrins with nicotinamide and N-(hydroxymethyl)nicotinamide in aqueous solution

被引：0
作者：
I. V. Terekhova
R. S. Kumeev
G. A. Al’per
机构：
[1] Russian Academy of Sciences,Institute of Solution Chemistry
来源：
Russian Journal of General Chemistry | 2010年 / 80卷
关键词：
General Chemistry; Cyclodextrin; Clathrate; Nicotinic Acid; Nicotinamide;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Complex formation of α- and β-cyclodextrins with biologically active nicotinamide and Nhydroxymethylnicotinamide (nicodine) was studied by calorimetry and 1H NMR spectroscopy. Cyclodextrins showed a weak complexing ability toward nicotinamide and nicodine: 1: 1 enthalpy-stabilized host-guest complexes were formed in aqueous solution at 298.15 K. Nicotinamide and nicodine molecules appeared inside the macrocycle cavity of cyclodextrins, but interaction between their polar side-chain groups with the outer surface of cyclodextrins cannot be ruled out. Thermodynamic parameters of the complexation process were calculated, and a mechanism was proposed for the observed interaction. The results were compared with those obtained previously for the complexation of cyclodextrins with nicotinic acid.
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页码：334 / 340
页数：6
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