Biomarkers in amyotrophic lateral sclerosis: opportunities and limitations

被引：0
作者：
Robert Bowser
Martin R. Turner
Jeremy Shefner
机构：
[1] Barrow Neurological Institute,Division of Neurology
[2] St Joseph's Hospital and Medical Center,Nuffield Department of Clinical Neurosciences
[3] Oxford University,Department of Neurology
[4] John Radcliffe Hospital,undefined
[5] State University of New York,undefined
[6] Upstate Medical University,undefined
来源：
Nature Reviews Neurology | 2011年 / 7卷
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学科分类号：
摘要：
Research into amyotrophic lateral sclerosis (ALS) has improved our understanding of the molecular mechanisms underlying disease pathogenesis, but diagnosis of patients with ALS has remained difficult. Bowseret al. highlight recent discoveries of biomarkers for ALS—from proteins in biofluids to neurophysiological and neuroimaging findings—and discuss the benefits and limitations of these biomarkers as diagnostic and prognostic indicators of disease.
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页码：631 / 638
页数：7
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