Cardioprotective and renoprotective effects of melatonin and vitamin E on fluoride-induced hypertension and renal dysfunction in rats

被引：0

作者：

Oyagbemi A.A. ^{[1
]}

Ajibade T.O. ^{[1
]}

Esan O.O. ^{[2
]}

Adetona M.O. ^{[3
]}

Awoyomi O.V. ^{[4
]}

Omobowale T.O. ^{[2
]}

Ola-Davies O.E. ^{[1
]}

Saba A.B. ^{[5
]}

Adedapo A.A. ^{[5
]}

Nkadimeng S.M. ^{[6
]}

McGaw L.J. ^{[7
]}

Kayoka-Kabongo P.N. ^{[8
]}

Yakubu M.A. ^{[9
]}

Nwulia E. ^{[10
]}

Oguntibeju O.O. ^{[11
]}

机构：

[1] Department of Veterinary Physiology and Biochemistry, Faculty of Veterinary Medicine, University of Ibadan, Ibadan

[2] Department of Veterinary Medicine, Faculty of Veterinary Medicine, University of Ibadan, Ibadan

[3] Department of Anatomy, Faculty of Basic Medical Sciences, University of Ibadan, Ibadan

[4] Federal College of Animal Health and Production Technology, Moor Plantation, Ibadan

[5] Department of Veterinary Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Ibadan, Ibadan

[6] Department of Life and Consumer Sciences, College of Agriculture and Environmental Sciences, University of South Africa Florida Campus, University of South Africa, Florida

[7] Phytomedicine Programme, Department of Paraclinical Science, Faculty of Veterinary Science, University of Pretoria, Old Soutpan Road, Onderstepoort

[8] Department of Agriculture and Animal Health, College of Agriculture and Environmental Sciences, University of South Africa, Florida

[9] Department of Environmental and Interdisciplinary Sciences, College of Science, Engineering & Technology, COPHS, Texas Southern University, Houston, TX

[10] Howard University, College of Medicine, Department of Psychiatry and Behavioral Sciences, Howard University Hospital, 2041 Georgia Avenue, Washington, 20060, DC

[11] Department of Biomedical Sciences, Faculty of Health and Wellness Sciences, Cape Peninsula University of Technology, Bellville

来源：

Comparative Clinical Pathology | 2024年 / 33卷 / 1期

关键词：

Fluoride; Hypertension; Melatonin; Rat; Vitamin E;

D O I：

10.1007/s00580-023-03519-5

中图分类号：

学科分类号：

摘要：

Fluoride is an important toxicological and environmental toxicant that is implicated in diverse cardiorenal system dysfunctions via the induction of oxidative stress. The present study aims at evaluating the cardioprotective and renoprotective effects of melatonin and vitamin E on fluoride toxicity on biomarkers of oxidative stress, clinical pathology, and their molecular mechanism of action. Apparently healthy male rats of the Wistar strain (n = 50; 160 ± 7.5 g), were randomly distributed into five groups of ten animals per group as follows: Control, sodium fluoride (NaF, 25 mg/kg), NaF and melatonin 20 mg/kg i.p.; NaF and vitamin E 50 mg/kg p/o, NaF plus melatonin and vitamin E administered orally. NaF and melatonin were administered for fifteen consecutive days, whereas vitamin E was administered every 72 h. Blood pressure parameters, oxidative stress biomarkers, electrocardiography, histopathology, and immunohistochemical staining were performed. From this study, NaF intoxication provoked reduction in renal and cardiac systemic antioxidants, alterations of haemodynamic and electrocardiographic parameters, heightened blood urea nitrogen (BUN), creatinine, angiotensin converting enzyme, angiotensin 2 type 1 receptor, kidney injury molecule 1, interleukin 1 beta in the renal tissues, cardiac troponin, and nuclear kappa beta. However, the administration of either melatonin or vitamin E, and its combination mitigated high blood pressure, normalized electrocardiographic changes, abrogated biomarkers of oxidative stress, improved renal function, and attenuated inflammation. The combination of melatonin and vitamin E effectively mitigated cardiovascular and renal toxicities associated with fluoride intoxication through the prevention of cardio-renal dysfunction, oxidative stress, and inflammatory processes. © The Author(s), under exclusive licence to Springer-Verlag London Ltd., part of Springer Nature 2023.

引用

页码：33 / 45

页数：12

共 63 条

[1]

Abd-Allah E.R., El-Rahman H.A.A., Ameliorative effects of nano Moringa on fluoride-induced testicular damage via down regulation of the StAR gene and altered steroid hormones, Reprod Biol, 23, 1, (2022)

[2]

Abdollahi M., Momen-Heravi F., Encyclopedia of Toxicology, 3rd Edition, 606–610, (2014)

[3]

Agalakova N.I., Gusev G.P., Fluoride induces oxidative stress and ATP depletion in the rat erythrocytes in vitro, Environ Toxicol Pharmacol, 34, 2, pp. 334-337, (2012)

[4]

Ajibade T., Bolaji-Alabi F., Oyagbemi A., Ajileye I., Omobowale T., Supplementation of antihypertensive drug regimen with vitamin E ameliorates alterations of primary haemodynamic parameters and total antioxidant capacity in ovariectomised rats, J Basic Clin Physiol Pharmacol, (2021)

[5]

Ajibade T.O., Awodele O.A., Tijani M.O., Adejumobi O.A., Adetona M.O., Oyagbemi A.A., Adedapo A.D., Omobowale T.O., Aro A.O., Ola-Davies O.E., Saba A.B., Adedapo A.A., Nkadimeng S.M., McGaw L.J., Kayoka-Kabongo P.N., Oguntibeju O.O., Yakubu M.A., L-arginine and lisinopril supplementation protects against sodium fluoride-induced nephrotoxicity and hypertension by suppressing mineralocorticoid receptor and angiotensin-converting enzyme 3 activity, Environ Sci Pollut Res Int, (2022)

[6]

Ajibade T.O., Oyagbemi A.A., Durotoye L.A., Omobowale T.O., Asenuga E.R., Olayemi F.O., Modulatory effects of melatonin and vitaminâ€†C on oxidative stress-mediated haemolytic anaemia and associated cardiovascular dysfunctions in rats, J Integr Comp Med, 14, 1, (2017)

[7]

Amini H., Mahmood T., Mohamad A., Majid M., Yaser M., Masoud Y., Drinking water fluoride and blood pressure? An environmental study, Bio Trace Elem Res, 144, pp. 157-163, (2011)

[8]

Azab A., Albasha M., Jbireal J., Adwas A., Sodium fluoride induces hepato-renal oxidative stress and pathophysiological changes in experimental animals, Open J Apoptosis, 7, pp. 1-23, (2018)

[9]

Aziz F.M., Maulood I.M., Chawsheen M.A.H., Effects of melatonin, vitamin C and E alone or in combination on lead-induced injury in liver and kidney organs of rats, IOSR J Pharm, 22, pp. 13-18, (2012)

[10]

Borghi C., Cicero A.F., Nutraceuticals with clinically detectable blood pressure lowering effect: a review of available randomized clinical trials and their meta-analyses, Brit J Clin Pharmacol, 83, pp. 163-171, (2017)

← 1 2 3 4 5 6 7 →