Inhibition of ERK1/2 in cancer-associated pancreatic stellate cells suppresses cancer–stromal interaction and metastasis

被引:0
作者
Zilong Yan
Kenoki Ohuchida
Shuang Fei
Biao Zheng
Weiyu Guan
Haimin Feng
Shin Kibe
Yohei Ando
Kazuhiro Koikawa
Toshiya Abe
Chika Iwamoto
Koji Shindo
Taiki Moriyama
Kohei Nakata
Yoshihiro Miyasaka
Takao Ohtsuka
Kazuhiro Mizumoto
Makoto Hashizume
Masafumi Nakamura
机构
[1] Graduate School of Medical Sciences,Department of Surgery and Oncology
[2] Kyushu University,Department of Advanced Medical Initiatives
[3] Graduate School of Medical Sciences,Department of General Surgery
[4] Kyushu University,undefined
[5] Shenzhen University General Hospital,undefined
[6] Cancer Center of Kyushu University Hospital,undefined
来源
Journal of Experimental & Clinical Cancer Research | / 38卷
关键词
ERK1/2; Pancreatic cancer; Cancer–stromal interaction; Pancreatic stellate cell; Cellular senescence;
D O I
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[1]  
Hess KR(2006)Metastatic patterns in adenocarcinoma Cancer. 106 1624-1633
[2]  
Varadhachary GR(2007)Is resection of periampullary or pancreatic adenocarcinoma with synchronous hepatic metastasis justified? Cancer. 110 2484-2492
[3]  
Taylor SH(2015)Desmoplasia in primary tumors and metastatic lesions of pancreatic cancer Clin Cancer Res 21 3561-3568
[4]  
Wei W(2007)Roles of the Raf/MEK/ERK pathway in cell growth, malignant transformation and drug resistance Biochim Biophys Acta - Mol Cell Res 1773 1263-1284
[5]  
Raber MN(2011)Ras/Raf/MEK/ERK pathway is associated with lung metastasis of osteosarcoma in an orthotopic mouse model Anticancer Res 31 1147-1152
[6]  
Lenzi R(2013)Targeting the ERK pathway reduces liver metastasis of Smad4-inactivated colorectal cancer Cancer Biol Ther 14 1059-1067
[7]  
Gleisner AL(2017)TGFβ engages MEK/ERK to differentially regulate benign and malignant pancreas cell function Oncogene 36 4336-4348
[8]  
Assumpcao L(2016)Long-Term ERK Inhibition in KRAS-Mutant Pancreatic Cancer Is Associated with MYC Degradation and Senescence-like Growth Suppression Cancer Cell 29 75-89
[9]  
Cameron JL(2010)CD10+ Pancreatic Stellate Cells Enhance the Progression of Pancreatic Cancer Gastroenterology 139 1041-1051.e8-3222
[10]  
Wolfgang CL(2004)Radiation to stromal fibroblasts increases invasiveness of pancreatic Cancer cells through tumor-stromal interactions Cancer Res 64 3215-338