Mechanisms of Disease: oncogene addiction—a rationale for molecular targeting in cancer therapy

被引：0
作者：
I Bernard Weinstein
Andrew K Joe
机构：
[1] Frode Jensen Professor of Medicine,
[2] Genetics and Development,undefined
[3] and Public Health at the College of Physicians and Surgeons,undefined
[4] Columbia University,undefined
[5] Florence Irving Assistant Professor of Clinical Medicine,undefined
[6] College of Physicians and Surgeons,undefined
[7] Columbia University,undefined
来源：
Nature Clinical Practice Oncology | 2006年 / 3卷
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学科分类号：
摘要：
The oncogene addition concept was established to explain how some cancers that contain multiple genetic, epigenetic, and chromosomal abnormalities are dependent on or are “addicted” to one or more genes for both maintenance of the malignant phenotype and cell survival. Weinstein and Joe summarize current experimental and clinical evidence of this concept and describe some of the molecular mechanisms of this phenomenon. The use of molecular targeted agents in combination with cytotoxic agents, and the advances in systems biology and network theory can help to facilitate an optimal treatment approach.
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页码：448 / 457
页数：9
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