Mechanisms of Disease: oncogene addiction—a rationale for molecular targeting in cancer therapy

被引：0
作者：
I Bernard Weinstein
Andrew K Joe
机构：
[1] Frode Jensen Professor of Medicine,
[2] Genetics and Development,undefined
[3] and Public Health at the College of Physicians and Surgeons,undefined
[4] Columbia University,undefined
[5] Florence Irving Assistant Professor of Clinical Medicine,undefined
[6] College of Physicians and Surgeons,undefined
[7] Columbia University,undefined
来源：
Nature Clinical Practice Oncology | 2006年 / 3卷
关键词：
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The oncogene addition concept was established to explain how some cancers that contain multiple genetic, epigenetic, and chromosomal abnormalities are dependent on or are “addicted” to one or more genes for both maintenance of the malignant phenotype and cell survival. Weinstein and Joe summarize current experimental and clinical evidence of this concept and describe some of the molecular mechanisms of this phenomenon. The use of molecular targeted agents in combination with cytotoxic agents, and the advances in systems biology and network theory can help to facilitate an optimal treatment approach.
引用
收藏
页码：448 / 457
页数：9
相关论文
共 84 条
  • [1] Weinstein IB(1997)Disorders in cell circuitry associated with multistage carcinogenesis: exploitable targets for cancer prevention and therapy Clin Cancer Res 3 2696-2702
  • [2] Weinstein IB(2000)Disorders in cell circuitry during multistage carcinogenesis: the role of homeostasis Carcinogenesis 21 857-864
  • [3] Weinstein IB(2002)Cancer. Addiction to oncogenes—the Achilles heal of cancer Science 297 63-64
  • [4] Sawyers C(2004)Targeted cancer therapy Nature 432 294-297
  • [5] Kaelin WG(2005)The concept of synthetic lethality in the context of anticancer therapy Nat Rev Cancer 5 689-698
  • [6] Felsher DW(1999)Reversible tumorigenesis by MYC in hematopoietic lineages Mol Cell 4 199-207
  • [7] Bishop JM(2000)Reversibility of acute B-cell leukaemia induced by BCR-ABL1 Nat Genet 24 57-60
  • [8] Huettner CS(1999)Essential role for oncogenic Ras in tumour maintenance Nature 400 468-472
  • [9] Chin L(2001)Analysis of lung tumor initiation and progression using conditional expression of oncogenic K-ras Genes Dev 15 3243-3248
  • [10] Jackson EL(2002)Suppression of Myc-induced apoptosis in beta cells exposes multiple oncogenic properties of Myc and triggers carcinogenic progression Cell 109 321-334
123456789