Polymethylene Derivatives of Nucleic Bases with ω-Functional Groups: II. Adenine and Hypoxanthine Derivatives

被引：0
作者：
A. A. Makinsky
A. M. Kritzyn
E. A. Ul'yanova
O. D. Zakharova
D. V. Bugreev
G. A. Nevinsky
机构：
[1] Russian Academy of Sciences,Engelhardt Institute of Molecular Biology
[2] Russian Academy of Sciences,Novosibirsk Institute of Bioorganic Chemistry, Siberian Division
来源：
Russian Journal of Bioorganic Chemistry | 2001年 / 27卷
关键词：
nucleosides; polymethylene analogues; alkylation; HIV reverse transcriptase; human DNA topoisomerase I;
D O I：
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中图分类号：
学科分类号：
摘要：
N9-Polymethylene derivatives of adenine and hypoxanthine with various functional groups in the ω-position of the alkyl substituent were synthesized. Their physicochemical properties and effect on the HIV reverse transcriptase and DNA topoisomerase I were studied.
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页码：167 / 172
页数：5
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