Histone deacetylase (HDAC) inhibitors and doxorubicin combinations target both breast cancer stem cells and non-stem breast cancer cells simultaneously

被引:0
作者
Ling-Wei Hii
Felicia Fei-Lei Chung
Jaslyn Sian-Siu Soo
Boon Shing Tan
Chun-Wai Mai
Chee-Onn Leong
机构
[1] International Medical University,Department of Life Sciences, School of Pharmacy
[2] International Medical University,School of Postgraduate Studies and Research
[3] International Agency for Research on Cancer World Health Organization,Mechanisms of Carcinogenesis Section (MCA), Epigenetics Group (EGE)
[4] Cancer Research Malaysia,Institute of Biological Chemistry
[5] Sime Darby Medical Centre,Department of Pharmaceutical Chemistry, School of Pharmacy
[6] Academia Sinica,Centre for Cancer and Stem Cell Research, Institute for Research, Development and Innovation
[7] International Medical University,undefined
[8] International Medical University,undefined
来源
Breast Cancer Research and Treatment | 2020年 / 179卷
关键词
Breast cancer; Cancer stem cells; HDAC inhibitors; Quisinostat; Doxorubicin; Drug combination;
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
页码:615 / 629
页数:14
相关论文
共 534 条
[1]  
Batlle E(2017)Cancer stem cells revisited Nat Med 23 1124-1134
[2]  
Clevers H(2015)Single-cell analysis reveals a stem-cell program in human metastatic breast cancer cells Nature 526 131-135
[3]  
Lawson DA(2012)Antitumor effect of the mTOR inhibitor everolimus in combination with trastuzumab on human breast cancer stem cells in vitro and in vivo Tumor Biol 33 1349-1362
[4]  
Bhakta NR(2007)Activation of the PTEN/mTOR/STAT3 pathway in breast cancer stem-like cells is required for viability and maintenance Proc Natl Acad Sci 104 16158-16163
[5]  
Kessenbrock K(2008)The CDK inhibitors: potential targets for therapeutic stem cell manipulations? Gene Ther 15 117-1333
[6]  
Prummel KD(2013)A possible usage of a CDK4 inhibitor for breast cancer stem cell-targeted therapy Biochem Biophys Res Commun 430 1329-3988
[7]  
Yu Y(2013)The expression and significance of insulin-like growth factor-1 receptor and its pathway on breast cancer stem/progenitors Breast Cancer Res 15 R39-1313
[8]  
Takai K(2015)The role of the insulin-like growth factor-1 system in breast cancer Mol Cancer Res 14 1-5511
[9]  
Zhou A(2010)Insulin-like growth factor 1 (IGF1), IGF binding protein 3 (IGFBP3), and breast cancer risk: pooled individual data analysis of 17 prospective studies Lancet Oncol 11 530-1387
[10]  
Eyob H(2003)Prospective identification of tumorigenic breast cancer cells Proc Natl Acad Sci USA 100 3983-7511