Effects of human T-lymphotropic virus type II on human immunodeficiency virus type 1 phenotypic evolution

被引：0

作者：

P. C. Guenthner

R. C. Hershow

R. B. Lal

C. S. Dezzutti

机构：

[1] HIV and Retrovirology Branch,

[2] Division of AIDS,undefined

[3] STD,undefined

[4] and TB Laboratory Research,undefined

[5] Centers for Disease Control and Prevention,undefined

[6] Atlanta,undefined

[7] Georgia,undefined

[8] U.S.A.,undefined

[9] University of Illinois at Chicago,undefined

[10] College of Medicine and School of Public Health,undefined

[11] Chicago,undefined

[12] Illinois,undefined

[13] U.S.A.,undefined

来源：

Archives of Virology | 2001年 / 146卷

关键词：

Human Immunodeficiency Virus; Human Immunodeficiency Virus Type; Virus Type; Phenotypic Change; Primary Isolate;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Phenotypic change and broader coreceptor usage by HIV-1 have been associated with disease progression. HIV-1 coreceptor usage by primary isolates obtained from HIV-1-infected and HIV-1/HTLV-II-coinfected individuals was determined. HIV-1 was isolated from 15 of 20 HIV-1-infected and 17 of 24 HIV-1/HTLV-II-coinfected individuals. None of the isolates from either the HIV-1-infected or the coinfected group infected CCR5Δ32 PBMCs, suggesting that they all were R5-tropic. Further, both spontaneous and PHA-stimulated production of MIP-1β and RANTES were similar in HIV-1-infected and coinfected individuals. These data indicate that coinfection with HTLV-II has no effect on HIV-1 coreceptor usage or ex vivo β-chemokine production.

引用

页码：1617 / 1622

页数：5

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