Evaluation in vitro and in animals of a new 11C-labeled PET radioligand for metabotropic glutamate receptors 1 in brain

[1] Spooren W(2003)Insight into the function of group I and group II metabotropic glutamate (mGlu) receptors: behavioural characterization and implications for the treatment of CNS disorders Behav Pharmacol 14 257-277

[2] Ballard T(1997)Pharmacology and functions of metabotropic glutamate receptors Annu Rev Pharmacol Toxicol 37 205-237

[3] Gasparini F(2005)Metabotropic glutamate receptor 1 blockade impairs acquisition and retention in a spatial water maze task Behav Brain Res 164 52-60

[4] Amalric M(2008)Metabotropic glutamate 1 receptor: current concepts and perspectives Pharmacol Rev 60 536-581

[5] Mutel V(2006)Radiosynthesis and preclinical evaluation of 11C-ABP688 as a probe for imaging the metabotropic glutamate receptor subtype 5 J Nucl Med 47 698-705

[6] Schreiber R(2005)Synthesis, characterization, and first successful monkey imaging studies of metabotropic glutamate receptor subtype 5 (mGluR5) PET radiotracers Synapse 56 205-216

[7] Conn PJ(2007)Synthesis and simple 18F-labeling of 3-fluoro-5-(2-(2-(fluoromethyl)thiazol-4-yl)ethynyl)benzonitrile as a high affinity radioligand for imaging monkey brain metabotropic glutamate subtype-5 receptors with positron emission tomography J Med Chem 50 3256-3266

[8] Pin JP(2005)A positron emission tomography radioligand for the in vivo labeling of metabotropic glutamate 1 receptor: (3-ethyl-2-[11C]methyl-6-quinolinyl)(cis-4-methoxycyclohexyl)methanone J Med Chem 48 5096-5099

[9] Steckler T(2010)Radiosynthesis and evaluation of [(11)C]YM-202074 as a PET ligand for imaging the metabotropic glutamate receptor type 1 Nucl Med Biol 37 615-624

[10] Oliveira AF(2010)Synthesis, characterization, and monkey PET studies of [18F]MK-1312, a PET tracer for quantification of mGluR1 receptor occupancy by MK-5435 Synapse 65 125-135

[1] Spooren W(2003)Insight into the function of group I and group II metabotropic glutamate (mGlu) receptors: behavioural characterization and implications for the treatment of CNS disorders Behav Pharmacol 14 257-277

[2] Ballard T(1997)Pharmacology and functions of metabotropic glutamate receptors Annu Rev Pharmacol Toxicol 37 205-237

[3] Gasparini F(2005)Metabotropic glutamate receptor 1 blockade impairs acquisition and retention in a spatial water maze task Behav Brain Res 164 52-60

[4] Amalric M(2008)Metabotropic glutamate 1 receptor: current concepts and perspectives Pharmacol Rev 60 536-581

[5] Mutel V(2006)Radiosynthesis and preclinical evaluation of 11C-ABP688 as a probe for imaging the metabotropic glutamate receptor subtype 5 J Nucl Med 47 698-705

[6] Schreiber R(2005)Synthesis, characterization, and first successful monkey imaging studies of metabotropic glutamate receptor subtype 5 (mGluR5) PET radiotracers Synapse 56 205-216

[7] Conn PJ(2007)Synthesis and simple 18F-labeling of 3-fluoro-5-(2-(2-(fluoromethyl)thiazol-4-yl)ethynyl)benzonitrile as a high affinity radioligand for imaging monkey brain metabotropic glutamate subtype-5 receptors with positron emission tomography J Med Chem 50 3256-3266

[8] Pin JP(2005)A positron emission tomography radioligand for the in vivo labeling of metabotropic glutamate 1 receptor: (3-ethyl-2-[11C]methyl-6-quinolinyl)(cis-4-methoxycyclohexyl)methanone J Med Chem 48 5096-5099

[9] Steckler T(2010)Radiosynthesis and evaluation of [(11)C]YM-202074 as a PET ligand for imaging the metabotropic glutamate receptor type 1 Nucl Med Biol 37 615-624

[10] Oliveira AF(2010)Synthesis, characterization, and monkey PET studies of [18F]MK-1312, a PET tracer for quantification of mGluR1 receptor occupancy by MK-5435 Synapse 65 125-135