Brain expression quantitative trait locus mapping informs genetic studies of psychiatric diseases脑组织的表达数量性状遗传位点定位方法解析精神疾病遗传基础

被引：0
作者：
Chunyu Liu
机构：
[1] The University of Chicago,Department of Psychiatry and Behavioral Neuroscience
来源：
Neuroscience Bulletin | 2011年 / 27卷
关键词：
genome-wide association study; brain; psychiatric diseases; expression quantitative trait loci; genetics; single nucleotide polymorphism; 全基因组关联分析; 大脑; 精神疾病; 表达数量性状遗传位点; 遗传学; 单核苷酸多态;
D O I：
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学科分类号：
摘要：
Genome-wide association study (GWAS) can be used to identify genes that increase the risk of psychiatric diseases. However, much of the disease heritability is still unexplained, suggesting that there are genes to be discovered. Functional annotation of the genetic variants may increase the power of GWAS to identify disease genes, by providing prior information that can be used in Bayesian analysis or in reducing the number of tests. Expression quantitative trait loci (eQTLs) are genomic loci that regulate gene expression. Genetic mapping of eQTLs can help reveal novel functional effects of thousands of single nucleotide polymorphisms (SNPs). The present review mainly focused on the current knowledge on brain eQTL mapping, and discussed some major methodological issues and their possible solutions. The frequently ignored problems of batch effects, covariates, and multiple testing were emphasized, since they can lead to false positives and false negatives. The future application of eQTL data in GWAS analysis was also discussed.
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页码：123 / 133
页数：10
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