Sodium hypochlorite-mediated synthesis of 2,5-disubstituted 1,3,4-oxadiazoles from hydrazides and aldehydes

被引：0
|
作者：
Karuna Raman Paidi
Murali Krishna Kolli
Eeda Koti Reddy
Venkata Ramana Pedakotla
机构：
[1] Sri Krishnadevaraya University,Vignan’s Foundation for Science
[2] Technology and Research (Deemed to be University),undefined
来源：
Chemistry of Heterocyclic Compounds | 2020年 / 56卷
关键词：
acylhydrazone; aldehyde; hydrazide; oxadiazole; sodium hypochlorite; oxidative cyclization;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
A simple and convenient method for the synthesis of 2,5-disubstituted 1,3,4-oxadiazoles has been developed. Structurally divergent symmetrical and unsymmetrical 2,5-disubstituted 1,3,4-oxadiazoles can be obtained in moderate to high yields via NaOCl-mediated oxidative cyclization of N-acylhydrazones, generated in situ from aliphatic and aromatic hydrazides and aldehydes.
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页码：371 / 376
页数：5
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