Aluminum-Induced Synaptic Plasticity Impairment via PI3K-Akt-mTOR Signaling Pathway

被引：0

作者：

Huan Li

Xingli Xue

Liang Li

Yaqin Li

Yanni Wang

Tao Huang

Yanhong Wang

Huaxing Meng

Baolong Pan

Qiao Niu

机构：

[1] Shanxi Medical University,Department of Occupational Health, School of Public Health

[2] Shanxi Medical University,Key Lab of Environmental Hazard and Health of Shanxi Province

[3] Shanxi Medical University,Key Lab of Cellular Physiology of Education Ministry

来源：

Neurotoxicity Research | 2020年 / 37卷

关键词：

Aluminum; Synaptic plasticity; Phosphatidylinositol 3-kinase (PI3K); Protein kinase B (Akt); Mammalian target of rapamycin (mTOR);

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Aluminum (Al) is an environmental neurotoxin with extensive exposure by humans, but the molecular mechanism of its toxicity is still unclear. Several studies have indicated that exposure to aluminum can impair learning and memory function. The purpose of this study was to investigate the mechanism of LTP injury and the effect of aluminum exposure on related signal pathways. The results showed that the axonal dendrites of neurons in the hippocampal CA1 area of rats exposed to maltol aluminum showed neuritic beading and the dendritic spines were reduced. This resulted in dose-dependent LTP inhibition and led to impaired learning and memory function in rats. The PI3K-Akt-mTOR pathway may play a crucial role in this process.

引用

页码：996 / 1008

页数：12

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