Aluminum-Induced Synaptic Plasticity Impairment via PI3K-Akt-mTOR Signaling Pathway

被引：0
|
作者：
Huan Li
Xingli Xue
Liang Li
Yaqin Li
Yanni Wang
Tao Huang
Yanhong Wang
Huaxing Meng
Baolong Pan
Qiao Niu
机构：
[1] Shanxi Medical University,Department of Occupational Health, School of Public Health
[2] Shanxi Medical University,Key Lab of Environmental Hazard and Health of Shanxi Province
[3] Shanxi Medical University,Key Lab of Cellular Physiology of Education Ministry
来源：
Neurotoxicity Research | 2020年 / 37卷
关键词：
Aluminum; Synaptic plasticity; Phosphatidylinositol 3-kinase (PI3K); Protein kinase B (Akt); Mammalian target of rapamycin (mTOR);
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Aluminum (Al) is an environmental neurotoxin with extensive exposure by humans, but the molecular mechanism of its toxicity is still unclear. Several studies have indicated that exposure to aluminum can impair learning and memory function. The purpose of this study was to investigate the mechanism of LTP injury and the effect of aluminum exposure on related signal pathways. The results showed that the axonal dendrites of neurons in the hippocampal CA1 area of rats exposed to maltol aluminum showed neuritic beading and the dendritic spines were reduced. This resulted in dose-dependent LTP inhibition and led to impaired learning and memory function in rats. The PI3K-Akt-mTOR pathway may play a crucial role in this process.
引用
收藏
页码：996 / 1008
页数：12
相关论文
共 50 条
  • [1] Aluminum-Induced Synaptic Plasticity Impairment via PI3K-Akt-mTOR Signaling Pathway
    Li, Huan
    Xue, Xingli
    Li, Liang
    Li, Yaqin
    Wang, Yanni
    Huang, Tao
    Wang, Yanhong
    Meng, Huaxing
    Pan, Baolong
    Niu, Qiao
    NEUROTOXICITY RESEARCH, 2020, 37 (04) : 996 - 1008
  • [2] Aluminum-Induced Cognitive Impairment and PI3K/Akt/mTOR Signaling Pathway Involvement in Occupational Aluminum Workers
    Nan Shang
    Ping Zhang
    Shuo Wang
    Jianping Chen
    Rong Fan
    Jin Chen
    Tao Huang
    Yanhong Wang
    Jeremy Duncan
    Ling Zhang
    Qiao Niu
    Qinli Zhang
    Neurotoxicity Research, 2020, 38 : 344 - 358
  • [3] PI3K-AKT-mTOR pathway inhibitors
    Cortot, A
    Armand, JP
    Soria, JC
    BULLETIN DU CANCER, 2006, 93 (01) : 19 - 26
  • [4] PI3K-AKT-mTOR pathway and cancer
    Coutte, Laetitia
    Dreyer, Chantal
    Sablin, Marie-Paule
    Faivre, Sandrine
    Raymond, Eric
    BULLETIN DU CANCER, 2012, 99 (02) : 173 - 180
  • [5] A bibliometric analysis of the application of the PI3K-AKT-mTOR signaling pathway in cancer
    Deng, Zhengzheng
    Qing, Qiancheng
    Huang, Bo
    NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 2024, 397 (10) : 7255 - 7272
  • [6] PI3K-AKT-mTOR
    Besse, B.
    EUROPEAN JOURNAL OF CANCER, 2013, 49 : S14 - S14
  • [7] PI3K-AKT-mTOR signaling pathway: the intersection of allergic asthma and cataract
    Zhao, Yang
    Li, Xiangsheng
    Xu, Zhenzhen
    Hao, Lifang
    Zhang, Yanfen
    Liu, Zhongcheng
    PHARMAZIE, 2019, 74 (10): : 598 - 600
  • [8] Ziprasidone triggers inflammasome signaling via PI3K-Akt-mTOR pathway to promote atrial fibrillation
    Lu, Ming-Kun
    Huo, Yen-Nien
    Tai, Buh-Yuan
    Lin, Chih-Yuan
    Yang, Hsiang-Yu
    Tsai, Chien-Sung
    BIOMEDICINE & PHARMACOTHERAPY, 2024, 175
  • [9] Critical Roles of the PI3K-Akt-mTOR Signaling Pathway in Apoptosis and Autophagy of Astrocytes Induced by Methamphetamine
    Liu, Han-Qing
    An, Ya-Wen
    Hu, A-Zhen
    Li, Ming-Hua
    Wu, Jue-Lian
    Liu, Li
    Shi, Yu
    Cui, Guang-Hui
    Chen, Yun
    OPEN CHEMISTRY, 2019, 17 (01): : 96 - 104
  • [10] SUPPRESSION OF PI3K-AKT-MTOR SIGNALING PATHWAY IN PARADOXICAL EGF-INDUCED CELL DEATH
    Hong-Gyun, W.
    Kim, K.
    Jeon, S. -R.
    ANNALS OF ONCOLOGY, 2013, 24
12345