Imiquimod 5% as Adjuvant Therapy for Incompletely Excised Infiltrative Nodular Basal Cell Carcinoma and Dermoscopy to Monitor Treatment Response

被引：11
作者：
Roldán-Marín R. [1 ]
Toussaint-Caire S. [2 ]
机构：
[1] Universidad Nacional Autónoma de México, Mexico City
[2] Dermatology Department, Hospital General Dr. Manuel Gea González, Mexico City
来源：
Dermatology and Therapy | 2015年 / 5卷 / 4期
关键词：
Adjuvant; Basal cell; Carcinoma; Dermoscopy; Imiquimod;
D O I：
10.1007/s13555-015-0088-z
中图分类号：
学科分类号：
摘要：
Introduction: A relatively novel application for dermoscopy is its use in the monitoring of topical treatment response for non-melanoma skin cancer. Basal cell carcinoma (BCC) is the most frequent type of skin cancer in humans. Surgical excision is still considered the “gold-standard” of treatment. However, a number of topical therapies are now available for the treatment of different types of basal cell carcinoma. Case Report: This case report exemplifies the usefulness of dermoscopy in the monitoring of residual disease after incomplete surgical excision and also in the monitoring of topical treatment response. Imiquimod 5% cream acts as a topical immune response modifier promoting a Th-1 immune response enhancing the removal of neoplastic cells and has proven to reduce deregulated Hedgehog (HH)/GLI signal strength independent of Toll-like receptor signaling, which makes it a valuable adjuvant topical therapy for the treatment of basal cell carcinoma. Conclusion: Imiquimod 5% cream is a valuable adjuvant therapy for the treatment of incompletely excised BCC. This case report adds further evidence to the usefulness of dermoscopy in the assessment and monitoring of treatment outcome. © 2015, The Author(s).
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页码：265 / 272
页数：7
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