Histone Demethylases in Cancer

被引：0
作者：
Sainathan S. [1 ]
Paul S. [1 ]
Ramalingam S. [2 ]
Baranda J. [3 ]
Anant S. [1 ,2 ]
Dhar A. [1 ,2 ]
机构：
[1] Cancer Biology, University of Kansas Medical Center, 3901 Rainbow Blvd, Wahl East Building, Kansas City, 66160, KS
[2] Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, KS
[3] Hematology & Oncology, University of Kansas Medical Center, Kansas City, KS
来源：
Current Pharmacology Reports | 2015年 / 1卷 / 4期
基金：
美国国家卫生研究院;
关键词：
Cancer; DNA methylation; Epigenetics; Histone demethylases; Hypoxia;
D O I：
10.1007/s40495-015-0025-y
中图分类号：
学科分类号：
摘要：
Epigenetic regulation, which involves with covalent modifications of DNA and the protein that bundles DNA, namely histones, is an exciting and variable phenomenon that affects normal cellular genetic character and contributes to human diseases. One key histone modification is methylation, regulated by methyl transferases and demethylases. Recent studies have demonstrated that histone demethylases as new therapeutic targets in different diseases including cancers. In this manuscript, we summarize the current view of the histone demethylase families and their role as activators or repressors of various genes in cancer. It has been demonstrated that hypoxia is a driving force for the regulation of histone demethylases in different cancers. We have also discussed the latest development of the role of hypoxia in regulating histone demethylases and its effects on tumor progression. © 2015, Springer International Publishing AG.
引用
收藏
页码：234 / 244
页数：10
相关论文
共 132 条
  • [1] Kooistra S.M., Helin K., Molecular mechanisms and potential functions of histone demethylases, Nat Rev Mol Cell Biol, 13, 5, pp. 297-311, (2012)
  • [2] Berdasco M., Esteller M., Aberrant epigenetic landscape in cancer: how cellular identity goes awry, Dev Cell, 19, 5, pp. 698-711, (2010)
  • [3] Suganuma T., Workman J.L., Signals and combinatorial functions of histone modifications, Annu Rev Biochem, 80, pp. 473-499, (2011)
  • [4] Zentner G.E., Henikoff S., Regulation of nucleosome dynamics by histone modifications, Nat Struct Mol Biol, 20, 3, pp. 259-266, (2013)
  • [5] Biochim Biophys Acta., (2014)
  • [6] Albert M., Helin K., Histone methyltransferases in cancer, Semin Cell Dev Biol, 21, 2, pp. 209-220, (2010)
  • [7] Pedersen M.T., Helin K., Histone demethylases in development and disease, Trends Cell Biol, 20, 11, pp. 662-671, (2010)
  • [8] Histone demethylation mediated by the nuclear amine oxidase homolog LSD1., (2004)
  • [9] Epigenetic control and cancer: the potential of histone demethylases as therapeutic targets., (2012)
  • [10] Chen X., Hu Y., Zhou D.X., Epigenetic gene regulation by plant Jumonji group of histone demethylase, Biochim Biophys Acta, 1809, 8, pp. 421-426, (2011)
12345678910