Tumorigenic transformation by CPI-17 through inhibition of a merlin phosphatase

被引：0
作者：
Hongchuan Jin
Tobias Sperka
Peter Herrlich
Helen Morrison
机构：
[1] Leibniz Institute of Age Research–Fritz-Lipmann-Institute,Forschungszentrum Karlsruhe
[2] Institute of Toxicology and Genetics,Cancer Center, Department of Clinical Oncology, Prince of Wales Hospital
[3] The Chinese University of Hong Kong,undefined
来源：
Nature | 2006年 / 442卷
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摘要：
The phosphatase that activates the Merlin tumour suppressor (also known as neurofibromatosis 2) has been identified. It's a myosin phosphatase that is inhibited by the endogenous inhibitor CPI-17, which is often upregulated in human tumours and may contribute to the development of cancer by inactivating Merlin. Taken together, these findings point to a novel cascade of tumour suppressors whose action can be abolished in at least two ways, by mutation (NF2) or upregulation of the putative novel oncogene, CPI-17.
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页码：576 / 579
页数：3
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