Ca2+ Ions Regulate Activity of Na+,Cl–(HCO3−)-ATPase in the Mucosa of Rabbit Small Intestine

被引：0
|
作者：
V. A. Yurkiv
V. I. Melikhov
V. S. Shubin
机构：
[1] Central Research Institute of Epidemiology,Laboratory of Molecular Mechanisms for Infections
来源：
Bulletin of Experimental Biology and Medicine | 2015年 / 158卷
关键词：
secretory process; small intestine; transport ATPase; CFTR;
D O I：
暂无
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学科分类号：
摘要：
We studied the effects of bivalent metal ions on activity of Na+,Cl–(HCO3–)-ATPase was studied. In contrast to Ba2+, Co2+, Zn2+, and Mn2+ ions, Ca2+ and Mg2+ ions in a concentration of 0.25 mM completely inhibited this enzyme. Histamine in vivo significantly decreased the inhibiting effect of Ca2+ on Na+,Cl–(HCO3–)-ATPase. A possible mechanism of regulation of enzyme activity by Ca2+ ions and its possible relation with CFTR protein providing permeability of enterocyte apical membrane for Cl– ions was proposed.
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页码：326 / 328
页数：2
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