Respirable PLGA Microspheres Containing Rifampicin for the Treatment of Tuberculosis: Manufacture and Characterization

被引：0
作者：
Patrick O'Hara
Anthony J. Hickey
机构：
[1] University of North Carolina,Department of Biomedical Engineering
[2] Magellan Laboratories,Department of Drug Delivery and Disposition, School of Pharmacy and Department of Biomedical Engineering
[3] University of North Carolina,undefined
来源：
Pharmaceutical Research | 2000年 / 17卷
关键词：
tuberculosis; rifampicin; PLGA; biodegradable microspheres; aerosols; controlled release;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Purpose. Particles with aerodynamic diameters of 1–5μm deposit in the periphery of the lungs and are phagocytized by alveolarmacrophages, the primary site of Mycobacterium tuberculosisinfection. Aerosols of biodegradable polymeric microspheres containingantitubercular agents may be delivered to the lungs to improve the treatmentof tuberculosis.
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页码：955 / 961
页数：6
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