Transport of Pregabalin in Rat Intestine and Caco-2 Monolayers

被引：0
|
作者：
Nancy Jezyk
Cheng Li
Barbra H. Stewart
Xiaochun Wu
Howard N. Bockbrader
David Fleisher
机构：
[1] The University of Michigan,College of Pharmacy
[2] Parke-Davis Pharmaceutical Research Division,Pharmacokinetics/Dynamics and Metabolism Department
[3] Warner-Lambert Company,undefined
来源：
Pharmaceutical Research | 1999年 / 16卷
关键词：
Caco-2; carrier-mediated transport; rat intestine; large neutral amino acid (LNAA); intestinal absorption models;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Purpose. The purpose of this study was to determine if the intestinal transport of pregabalin (isobutyl -γ-aminobutyric acid, isobutyl GAB A), a new anticonvulsant drug, was mediated by amino acid carriers with affinity for large neutral amino acids (LNAA).
引用
收藏
页码：519 / 526
页数：7
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