Transforming growth factor-β: Recent advances on its role in immune tolerance

被引：40
作者：
Kriegel M.A. [1 ]
Li M.O. [1 ]
Sanjabi S. [1 ]
Wan Y.Y. [1 ]
Flavell R.A. [1 ]
机构：
[1] Howard Hughes Medical Institute, Yale University School of Medicine, Section of Immunobiology, New Haven, CT 06520
来源：
Current Rheumatology Reports | 2006年 / 8卷 / 2期
关键词：
Systemic Lupus Erythematosus; Immune Tolerance; Treg Function; Inhibit Natural Killer Cell; Tolerogenic Function;
D O I：
10.1007/s11926-006-0054-y
中图分类号：
学科分类号：
摘要：
Transforming growth factor-β (TGF-β) is a key regulator of immune tolerance. In this paper, we will focus on T cells and natural killer (NK) cells, which are directly regulated by TGF-β in vivo. TGF-β controls T-cell activation and differentiation, and is involved in the suppressive function and generation of regulatory T cells. Recently, TGF-β has also been shown to directly inhibit NK cell activity. These studies demonstrate that TGF-β utilizes multiple mechanisms to ensure immune tolerance, which is critical in a variety of autoimmune and inflammatory disorders. We will also discuss recent advances on the role of TGF-β in immune-mediated diabetes, inflammatory bowel disease, arthritis, and systemic lupus erythematosus. Copyright © 2006 by Current Science Inc.
引用
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页码：138 / 144
页数：6
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