In vivo Expression of the Collagen-Related Heat Shock Protein HSP47, Following Hyperthermia or Photodynamic Therapy

被引：0

作者：

A.K. Verrico

A.K. Haylett

J.V. Moore

机构：

[1] Laser Oncology Programme,

[2] CRC Dept of Experimental Radiation Oncology,undefined

[3] Paterson Institute for Cancer Research,undefined

[4] Christie Hospital (NHS) Trust,undefined

[5] Manchester,undefined

[6] UK,undefined

来源：

Lasers in Medical Science | 2001年 / 16卷

关键词：

Keywords: Heat shock protein 47; Hyperthermia; Photodynamic therapy; Stress response;

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学科分类号：

摘要：

Heat shock protein 47 (HSP 47), a molecule expressed constitutively in cells that synthesise collagen, is involved in collagen type I biosynthesis, and after insult acts as a stress response molecule to sequester abnormal procollagen. Photodynamic therapy (PDT) is claimed not to result in extensive collagen damage, such as that which can occur after other laser treatments, e.g. hyperthermia (HT) or coagulation, thereby conferring on PDT a potential therapeutic advantage. In previous studies on mouse fibroblasts in vitro we demonstrated HSP47 elevation in the first hours after the application of conditions known to damage collagen, and an absence of HSP47 elevation following PDT with two well-established photosensitisers, haematoporphyrin ester (HpE) and meta-tetrahydroxyphenylchlorin (mTHPC).

引用

页码：192 / 198

页数：6