Chlorhexidine is not effective at any concentration in preventing ventilator-associated pneumonia: a systematic review and network meta-analysis

被引:1
|
作者
De Cassai, Alessandro [1 ]
Pettenuzzo, Tommaso [2 ]
Busetto, Veronica [3 ]
Legnaro, Christian [4 ]
Pretto, Chiara [4 ]
Rotondi, Alessio [4 ]
Boscolo, Annalisa [2 ,4 ,5 ]
Sella, Nicolo [2 ]
Munari, Marina [1 ]
Navalesi, Paolo [2 ,4 ]
机构
[1] Univ Hosp Padua, St Antonio Anesthesia & Intens Care Unit, Padua, Italy
[2] Univ Hosp Padua, UOC Anesthesia & Intens Care Unit, Padua, Italy
[3] Univ Hosp Padua, Cardiac Surg Intens Care Unit, Padua, Italy
[4] Univ Padua, Dept Med DIMED, Padua, Italy
[5] Univ Padua, Dept Cardiac Thorac Vasc Sci & Publ Hlth, Thorac Surg & Lung Transplant Unit, Padua, Italy
来源
JOURNAL OF ANESTHESIA ANALGESIA AND CRITICAL CARE | 2024年 / 4卷 / 01期
关键词
Critical care; Chlorhexidine; Meta-analysis; Ventilator-associated pneumonia; Mechanical ventilation; INTENSIVE-CARE-UNIT; PLAQUE ANTISEPTIC DECONTAMINATION; NOSOCOMIAL INFECTIONS; ORAL RINSE; 2-PERCENT CHLORHEXIDINE; BACTERIAL-COLONIZATION; CARDIAC-SURGERY; 0.2-PERCENT; GLUCONATE; PREVALENCE;
D O I
10.1186/s44158-024-00166-2
中图分类号
R614 [麻醉学];
学科分类号
100217 ;
摘要
Introduction Oral chlorhexidine has been widely used for ventilator-associated pneumonia prevention in the critical care setting; however, previous studies and evidence synthesis have generated inconsistent findings. Our study aims to investigate if different concentrations of oral chlorhexidine may be effective in preventing such complication in intensive care unit patients. Methods After pre-registration (Open Science Framework: 8CUKF), we conducted a network meta-analysis with the following PICOS: adult patients (age > 18 years old) undergoing invasive mechanical ventilation admitted in ICU (P); any concentration of chlorhexidine used for oral hygiene (I); placebo, sham intervention, usual care, or no intervention (C); rate of VAP (primary outcome), mechanical ventilation length, ICU length of stay (LOS), hospital LOS, mortality (secondary outcomes) (O); randomized controlled trials (S). We used the following database: PubMed, the Cochrane Central Register of Controlled Trials (CENTRAL), Scopus, and EMBASE without any limitation in publication date or language. Results Chlorhexidine did not demonstrate any significant advantage over the control group in preventing ventilator-associated pneumonia or reducing mortality, duration of mechanical ventilation, length of stay in the intensive care unit, or overall mortality. Conclusions Chlorhexidine oral decontamination does not reduce the rate of ventilator-associated pneumonia in critically ill adult patients and its routine use could not be recommended.
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页数:9
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