Plasma fibronectin concentration in obese/overweight pregnant women: A possible risk factor for preeclampsia

被引：10
作者：
Ekaidem I.S. [1 ]
Bolarin D.M. [2 ]
Udoh A.E. [2 ]
Etuk S.J. [3 ]
Udiong C.E.J. [2 ]
机构：
[1] Department of Chemical Pathology, College of Health Science, University of Uyo, Uyo
[2] Department of Chemical Pathology, College of Medical Sciences, University of Calabar, Calabar
[3] Department of Obstetrics and Gynaecology, College of Medical Sciences, University of Calabar, Calabar
来源：
Indian Journal of Clinical Biochemistry | 2011年 / 26卷 / 2期
关键词：
Arterial pressure; Fibronectin; Obesity; Preeclampsia; Pregnancy; Risk factor;
D O I：
10.1007/s12291-011-0127-1
中图分类号：
学科分类号：
摘要：
Plasma fibronectin (FN) levels in obese/overweight and non-obese pregnant women were evaluated as a possible risk factor for preeclampsia. A total of one hundred and sixty three pregnant women attending antenatal clinic at University of Calabar Teaching Hospital participated in the study and sixty non-pregnant women served as control. About 77 (47.24%) of the pregnant women were followed up for any subsequent development of preeclampsia during the pregnancy. Fibronectin levels in plasma were measured by ELISA assay and serum total protein, urea and creatinine were determined spectrophotometrically. The mean plasma FN concentration of nonobese pregnant women in first trimester was lower than those of the non-pregnant women by 24%, but however, increased to the non-pregnant level in second and third trimesters. Obese/overweight pregnant women had significantly (P < 0.05) higher values than non-obese pregnant women in second and third trimesters. FN in obese/overweight pregnant women correlated positively with mean arterial blood pressure (MAP: r = 0.414, P = 0.04). About 28.57% of the pregnant women with FN above cut off point of 330 lg/ml at 18-24 weeks of gestation developed preeclampsia. This value increased to 40.0% when only the obese/overweight women were considered. On analysis of both fibronectin >330 μg/ml and MAP > 90, the predictive value increased to 66.7%. We therefore conclude that elevated FN may be regarded as a risk factor of preeclampsia especially among the obese women. © Association of Clinical Biochemists of India 2011.
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页码：187 / 192
页数：5
相关论文
共 31 条
[1]  
Santas A.J., Peterson J.A., Halbleib J.L., Craig S.E., Humphries M.J., Pesciotta P.D.M., Alternative splicing of the IIICS domain in fibronectin governs the role of the Heparin II domain in fibrillogenesis and cell spreading, Journal of Biological Chemistry, 277, 16, pp. 13650-13658, (2002)
[2]  
Mette N., Ozturk I.H., Colpan L., Plasma fibronectin and urine glycosaminoglycan levels in rheumatic disease, Trop J Med Sci, 28, pp. 437-441, (1998)
[3]  
Kanters S.D.J.M., Banga J.-D., Algra A., Frijns R.C.J.M., Beutler J.J., Fijnheer R., Plasma levels of cellular fibronectin in diabetes, Diabetes Care, 24, 2, pp. 323-327, (2001)
[4]  
Man S.F.P., Xing L., Connett J.E., Anthonisen N.R., Wise R.A., Tashkin D.P., Zhang X., Vessey R., Walker T.G., Celli B.R., Sin D.D., Circulation fibronectin to C-reactive protein ratio and mortality: A biomarker in COPD?, Eur Respir J, 32, pp. 1451-1457, (2008)
[5]  
Song K.S., Kim H.K., Shim W., Jee S.H., Plasma fibronectin levels in ischemic heart disease, Atherosclerosis, 154, 2, pp. 449-453, (2001)
[6]  
Waalkes S., Atschekzei F., Kramer M.W., Hennenlotter J., Vetter G., Becker J.U., Stenzl A., Merseburger A.S., Schrader A.J., Kuczyk M.A., Serth J., Fibronectin 1 mRNA expression correlates with advanced disease in renal cancer, BMC Cancer, 10, pp. 503-509, (2010)
[7]  
Warawdekar U.M., Zingde S.M., Iyer K.S.N., Jagannath P., Mehta A.R., Mehta N.G., Elevated levels and fragmented nature of cellular fibronectin in the plasma of gastrointestinal and head and neck cancer patients, Clinica Chimica Acta, 372, 1-2, pp. 83-93, (2006)
[8]  
Orem C., Celik S.O., Orem A., Calapolu M., Erdol C., Increased plasma fibronectin levels in patients with acute myocardial infarction complicated with left ventricular thrombus, Thrombosis Research, 105, 1, pp. 37-41, (2002)
[9]  
Orem C., Durmus I., Kilinc K., Baykan M., Gokce M., Orem A., Topbas M., Plasma fibronectin level and its association with coronary artery disease and carotid intima-media thickness, Coronary Artery Disease, 14, 3, pp. 219-224, (2003)
[10]  
Peters J.H., Loredo G.A., Chen G., Maunder R., Hahn T.J., Willits N.H., Hynes R.O., Plasma levels of fibronectin bearing the alternatively spliced EIIIB segment are increased after major trauma, Journal of Laboratory and Clinical Medicine, 141, 6, pp. 401-410, (2003)
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