Characterization of red blood cell deformability induced by acoustic radiation force

被引：0
作者：
Yifan Liu
Fengxian Xin
机构：
[1] Xi’an Jiaotong University,State Key Laboratory for Strength and Vibration of Mechanical Structures
[2] Xi’an Jiaotong University,MOE Key Laboratory for Multifunctional Materials and Structures
来源：
Microfluidics and Nanofluidics | 2022年 / 26卷
关键词：
Cell deformability; Acoustic radiation force; Large deformation; Microfluidics;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
A cyclic coupling computational model is developed to investigate the large deformation of swollen red blood cells (RBCs) induced by the acoustic radiation force arising from an ultrasonic standing wave field. The RBC consists of an internal fluid enclosed by a thin elastic membrane. Based on the acoustic radiation stress tensor theory, the acoustic radiation force exerted on the cell membrane is calculated. A continuum mechanical theory is adopted to model the mechanical response of the membrane, which is capable of accounting for the in-plane and bending deformation of the cell membrane. The cyclic coupling computation of the acoustic fields and mechanical deformation is realized in a finite element model. With the developed model, the acoustic deformation of a single cell is calculated and results are compared with the semi-analytical solutions for validation purposes. Then, the multiple cell deformation is considered, showing that the multiple cell deformation is influenced by the secondary acoustic radiation force arising due to cell–cell interaction. This work provides an accurate numerical approach to predict the acoustic deformability of cells, which might help explore the application of the ultrasonic technique in disease diagnosis and in promoting stem cell differentiation.
引用
收藏
相关论文
共 182 条
[11]  
Skalak R(2001)The optical stretcher: a novel laser tool to micromanipulate cells Biophys J 81 767-22
[12]  
Usami S(2017)Theory and algorithms to compute Helfrich bending forces: a review J Phys Condes Matter 29 30-960
[13]  
Chowdhury F(2000)Micropipette aspiration of living cells J Biomech 33 15-4230
[14]  
Na S(2010)Interaction of acoustic levitation field with liquid reflecting surface J Appl Phys 107 4-1572
[15]  
Li D(2004)Imaging morphological details and pathological differences of red blood cells using tapping-mode AFM Biol Chem 385 955-1094
[16]  
Poh YC(2017)Plasmodium falciparum erythrocyte-binding antigen 175 triggers a biophysical change in the red blood cell that facilitates invasion Proc Natl Acad Sci U S A 114 4225-1109
[17]  
Tanaka TS(2010)On the equilibrium equation for a generalized biological membrane energy by using a shape optimization approach Phys D 239 1567-3719
[18]  
Wang F(2006)Radiation forces exerted on arbitrarily located sphere by acoustic tweezer J Acoust Soc Am 120 1084-2036
[19]  
Wang N(1993)Acoustic radiation pressure J Acoust Soc Am 94 1099-2476
[20]  
Dziuk G(2005)Spectrin-level modeling of the cytoskeleton and optical tweezers stretching of the erythrocyte Biophys J 88 3707-553
12345678910