Functional Status and Well-Being in People with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Compared with People with Multiple Sclerosis and Healthy Controls

被引：46
作者：
Kingdon C.C. [1 ]
Bowman E.W. [1 ]
Curran H. [1 ]
Nacul L. [1 ]
Lacerda E.M. [1 ]
机构：
[1] International Centre for Evidence in Disability, Department of Clinical Research, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London
来源：
PharmacoEconomics - Open | 2018年 / 2卷 / 4期
关键词：
D O I：
10.1007/s41669-018-0071-6
中图分类号：
学科分类号：
摘要：
Background: People with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) continue to struggle to have their condition recognised as disabling in the face of public and professional prejudice and discrimination. Objective: The aim of this study was to compare the functional status and well-being of people with well-characterised ME/CFS with people with multiple sclerosis (PWMS), as well as healthy controls (HCs). Methods: In this cross-sectional study, we used data collected as part of the UK ME/CFS Biobank to compare actual participant scores from the Medical Outcomes Survey Short Form-36 v2™ (SF-36v2™) between groups, as a proxy for impact of disability, and from a bespoke questionnaire seeking data on employment and income. Results: People with ME/CFS scored significantly lower than PWMS or HCs in almost all SF-36v2™ areas. Prominent were lower scores for people with ME/CFS in the Physical Component Summary and Role Physical and Social Function domains, while the smallest differences were seen in the Mental Health domain. Responses to the bespoke questionnaire indicated that people with ME/CFS in this study work fewer hours and have lower incomes compared with people in the other two groups. Conclusions: Using SF-36v2™ scores as a proxy, people with ME/CFS were measurably more disabled than PWMS or HCs in this study population. Furthermore, employment and income data are consistent with loss of functional status. These findings should encourage the health community to recognise the disabling effects of ME/CFS, to advocate for the needs of people with ME/CFS, and to investigate strategies to address the cost of the disease to both individuals and society. © 2018, The Author(s).
引用
收藏
页码：381 / 392
页数：11
相关论文
共 53 条
  • [1] Olive M., The politics of disablement: a sociological approach critical texts in social work and the welfare state, (1990)
  • [2] ESA—changes to the Working Capability Assessment Descriptors, (2011)
  • [3] Strassheim V., Et al., What is known about severe and very severe chronic fatigue syndrome? A scoping review, Fatigue Biomed Health Behav., 5, 3, pp. 167-183, (2017)
  • [4] Cella M., Sharpe M., Chalder T., Measuring disability in patients with chronic fatigue syndrome: reliability and validity of the Work and Social Adjustment Scale, J Psychosom Res, 71, 3, pp. 124-128, (2011)
  • [5] Dinos S., Et al., A systematic review of chronic fatigue, its syndromes and ethnicity: prevalence, severity, co-morbidity and coping, Int J Epidemiol, 38, pp. 1554-1570, (2009)
  • [6] Prins J., van der Meer J., Bleijenberg G., Chronic fatigue syndrome, Lancet, 367, pp. 346-355, (2006)
  • [7] Bakken I., Et al., Two age peaks in the incidence of chronic fatigue syndrome/myalgic encephalomyelitis: a population-based registry study from Norway 2008 inverted question mark 2012, BMC Med., 12, 1, (2014)
  • [8] Nacul L.C., Et al., Prevalence of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) in three regions of England: a repeated cross-sectional study in primary care, BMC Med., 9, 1, (2011)
  • [9] Ross S., Et al., Disability and chronic fatigue syndrome, Arch Intern Med, 164, pp. 1098-1105, (2004)
  • [10] Nacul L.K., Kingdon C.C., Bowman E.W., Curran H., Lacerda E.M., Differing case definitions point to the need for an accurate diagnosis of myalgic encephalomyelitis/chronic fatigue syndrome, Fatigue Biomed Health Behav., 5, 1, pp. 1-4, (2017)
123456