Increased in cyclooxygenase—2 immunoreactivity and DNA damage in hippocampus of rats infected by Trypanosoma evansi

被引：1

作者：

Baldissera M.D. ^{[1
]}

Sagrillo M.R. ^{[2
]}

de Sá M.F. ^{[1
]}

Peroza L.R. ^{[3
]}

Posser C.P. ^{[2
]}

de Brum G.F. ^{[2
]}

Peres D.S. ^{[2
]}

De Mello A.L.B. ^{[2
]}

Ferrão M. ^{[2
]}

Souza C.F. ^{[1
]}

da Silva A.S. ^{[4
]}

Monteiro S.G. ^{[1
]}

机构：

[1] Department of Microbiology and Parasitology, Universidade Federal de Santa Maria (UFSM), Santa Maria, RS

[2] Laboratory of Cell Culture, Centro Universitário Franciscano, Santa Maria, RS

[3] Laboratory of Molecular Biology, Centro Universitário Franciscano, Santa Maria, RS

[4] Department of Animal Science, Universidade do Estado de Santa Catarina (UDESC), Chapecó, SC

来源：

Comparative Clinical Pathology | 2016年 / 25卷 / 3期

关键词：

Genotoxicity; Memory; Western blotting; Surra;

D O I：

10.1007/s00580-016-2235-z

中图分类号：

学科分类号：

摘要：

Cyclooxygenase-2 (COX-2) is one of the two isoforms of COX producing prostaglandins derived from arachidonic acid. COX-2 is the inducible isoform expressed in many cell types in response to cytokines and pro-inflammatory molecules. In brain, COX-2 is frequently associated with pro-inflammatory activities, and its increase is related to neurodegenerative processes in acute and chronic diseases. Thus, the aim of this study was to evaluate the COX-2 immunoreactivity and the frequency damage caused by T. evansi infection on days 5 and 15 post-infection (PI) in hippocampus cells, as well as the relationship with behavioral alterations. Decreased (p < 0.05) memory was observed in infected rats on days 5 and 15 PI. An increase in COX-2 immunoreactivity was observed in hippocampus of infected rats on day 15 PI (p < 0.05). Similarly, there was an increase in the frequency of damage in hippocampus of infected rats on days 5 and 15 PI (p < 0.05). This increment on COX-2 immunoreactivity may be associated with pro-inflammatory activities. Such activities are related to neurodegenerative alterations, as observed in histopathological analyses, and contribute to neurological pathophysiology of trypanosomosis. © 2016, Springer-Verlag London.

引用

页码：585 / 591

页数：6

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