Inhibiton of polyamine biosynthesis in Acanthamoeba castellanii and 12-O-tetradecanoylphorbol-13-acetate-induced ornithine decarboxylase activity by chitosanoligosaccharide

被引：0
|
作者：
Yun-Hee Shon
Kyung-Soo Nam
机构：
[1] Dongguk University,Department of Pharmacology, College of Medicine and Intractable Disease Research Center
来源：
Biotechnology Letters | 2003年 / 25卷
关键词：
chitosanoligosaccharide; ornithine decarboxylase; polyamine; tumour promotion;
D O I：
暂无
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学科分类号：
摘要：
Growth of Acanthamoeba castellaniiwas inhibited by chitosanoligosaccharide (up to 20 mg ml−1) from the shells of crabs but was reversed by the polyamines, putrescine or spermidine, at 0.8 mM. Chitosanoligosaccharide strongly inhibited the induction of ornithine decarboxylase by 12-O-tetradecanoylphorbol-13-acetate, a key enzyme of polyamine biosynthesis, which is enhanced in tumour promotion.
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页码：701 / 704
页数：3
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