Effect of 6-months of physical exercise on the nitrate/nitrite levels in hypertensive postmenopausal women

被引：34

作者：

Zaros P.R. ^{[1
]}

Pires C.E.M.R. ^{[1
]}

Bacci Jr. M. ^{[2
]}

Moraes C. ^{[3
]}

Zanesco A. ^{[1
]}

机构：

[1] Department of Physical Education, Institute of Biosciences, University of Sao Paulo State (UNESP), Rio Claro, SP

[2] Departmento of Biochemistry, University of Sao Paulo State (UNESP), Rio Claro, SP

[3] Institute of Physical Activity and Sports, Cruzeiro do Sul University, Sao Paulo, SP

来源：

BMC Women's Health | / 9卷 / 1期

基金：

巴西圣保罗研究基金会;

关键词：

Nitric Oxide; Postmenopausal Woman; Exercise Training; Physical Exercise; Arterial Hypertension;

D O I：

10.1186/1472-6874-9-17

中图分类号：

学科分类号：

摘要：

Background: Evidences have showed that the incidence of arterial hypertension is greater in postmenopausal women as compared to premenopausal. Physical inactivity has been implicated as a major contributor to weight gain and abdominal obesity in postmenopausal women and the incidence of cardiovascular disease increases dramatically after menopause. Additionally, more women than men die each year of coronary heart disease and are twice as likely as men to die within the first year after a heart attack. A healthy lifestyle has been strongly associated with the regular physical activity and evidences have shown that physically active subjects have more longevity with reduction of morbidity and mortality. Nitric oxide (NO) produced by endothelial cells has been implicated in this beneficial effect with improvement of vascular relaxing and reduction in blood pressure in both laboratory animals and human. Although the effect of exercise training in the human cardiovascular system has been largely studied, the majority of these studies were predominantly conducted in men or young volunteers. Therefore, the aim of this work was to investigate the effects of 6 months of dynamic exercise training (ET) on blood pressure and plasma nitrate/nitrite concentration (NOx-) in hypertensive postmenopausal women. Methods: Eleven volunteers were submitted to the ET consisting in 3 days a week, each session of 60 minutes during 6 months at moderate intensity (50% of heart rate reserve). Anthropometric parameters, blood pressure, NOx- concentration were measured at initial time and after ET. Results: A significant reduction in both systolic and diastolic blood pressure values was seen after ET which was accompanied by markedly increase of NOx- levels (basal: 10 ± 0.9; ET: 16 ± 2 μM). Total cholesterol was significantly reduced (basal: 220 ± 38 and ET: 178 ± 22 mg/dl), whereas triglycerides levels were not modified after ET (basal: 141 ± 89 and ET: 147 ± 8 mg/dl). Conclusion: Our study shows that changing in lifestyle promotes reducftion of arterial pressure which was accompanied by increase in nitrite/nitrate concentration. Therefore, 6-months of exercise training are an important approach in management arterial hypertension and play a protective effect in postmenopausal women. © 2009 Zaros et al; licensee BioMed Central Ltd.

引用

共 22 条

[1]

Harrison-Bernard L.M., Raij L., Postmenopausal hypertension, Curr Hypertens Rep, 2, pp. 202-207, (2000)

[2]

Simkin-Silverman L., Wing R.R., Hansen D.H., Klem M.L., Pasagian-Macaulay A.P., Meilahn E.N., Kuller L.H., Prevention of cardiovascular risk factor elevations in healthy premenopausal women, Preventive Medicine, 24, pp. 509-517, (1995)

[3]

Lewis S.J., Whalen E.J., Beltz T.G., Johnson A.K., Role of the anterior region of the third ventricle in the cardiovascular responses produced by systemic injection of a nitric oxide synthase inhibitor, Brain Res, 830, pp. 191-194, (1999)

[4]

Zanesco A., Antunes E., Effects of exercise training on the cardiovascular system: Phamacological approaches, Pharmacol Ther, 114, pp. 307-317, (2007)

[5]

Murad F., Cellular signaling with nitric oxide and cyclic GMP, Braz J Med Biol Res, 32, 11, pp. 1317-1327, (1999)

[6]

Vanhoutte P.M., Endothelial control of vasomotor function, Cir Res, 67, pp. 572-575, (2003)

[7]

Traub O., Berk B.C., Laminar shear stress mechanisms by which endothelial cells transduce an atheroprotective force, Arterioscler Thromb Vasc Biol, 18, pp. 677-685, (1998)

[8]

Boo Y.C., Jo H., Flow-dependent regulation of endothelial nitric oxide synthase: Role of protein kinases, Am J Physiol Cell Physiol, 285, 3, (2003)

[9]

Kingwell B.A., Nitric oxide-mediated metabolic regulation during exercise: Effects of training in health and cardiovascular disease, FASEB JOURNAL, 14, pp. 1685-1696, (2000)

[10]

Grahan D.A., Rush J.W., Exercise training improves aortic endothelium-dependent vasorelaxation and determinants of nitric oxide bioavailabity in spontaneously hypertensive rats, Journal Appl Physiol, 96, pp. 2088-2096, (2004)

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