SENIEUR status of the originating cell donor negates certain ‘anti-immunosenescence’ effects of ebselen and N-acetyl cysteine in human T cell clone cultures

被引:0
作者
Shiva Marthandan
Robin Freeburn
Susanne Steinbrecht
Graham Pawelec
Yvonne Barnett
机构
[1] Jena Centre for Systems Biology of Ageing-JenAge,Leibniz Institute for Age Research
[2] Fritz Lipmann Institute,School of Science, University of the West of Scotland
[3] Paisley Campus,Tübingen Ageing and Tumour Immunology Group
[4] Center for Medical Research,School of Science and Technology
[5] University of Tübingen Clinical School,undefined
[6] College of Arts and Science,undefined
[7] Nottingham Trent University,undefined
[8] Clifton Lane,undefined
来源
Immunity & Ageing | / 11卷
关键词
Immunosenescence; Ebselen; NAC; Proliferative capacity; Lifespan; SENIEUR; DNA damage; GSH:GSSG ratio; MAP kinases; JNK; p38; ERK; Total glutathione;
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
相关论文
共 200 条
[1]  
Barnett YA(1995)Oxidant-induced stress response in lymphoid cells Biochem Mol Biol Int 37 273-281
[2]  
Brennan LA(2006)Role of oxidative stress in pathophysiology of peripheral neuropathy and modulation by NAC in rats Eur J Pain 10 573-579
[3]  
O’Farrell F(2000)The effects of carnosine on oxidative DNA damage levels and Mech Ageing Dev 121 203-215
[4]  
Hannigan BM(1997) lifespan in human peripheral blood derived CD4 Mutat Res 377 137-147
[5]  
Naik AK(2004) TCCs Exp Gerontol 39 491-498
[6]  
Tandan SK(2005) antioxidant status, DNA damage, mutation and DNA repair capacity in cultured lymphocytes from healthy 75–80 year old humans Exp Gerontol 40 976-981
[7]  
Dudhgaonkar SP(1998)An investigation of DNA excision repair in human CD4 Mech Ageing Dev 102 165-175
[8]  
Jadhav SH(2001) TCCs as a function of age Mech Ageing Dev 122 1151-1167
[9]  
Kataria M(2013)An investigation of DNA mismatch repair capacity under normal culture conditions and under conditions of supraphysiological challenge in human CD4 Immun Ageing 10 7-128
[10]  
Prakash VR(1995) TCCs from donors of different ages Mutat Res 338 115-4879