Assessment of the anti-angiogenic, anti-inflammatory and antinociceptive properties of ethyl vanillin

被引：0
作者：
Hyun-Joo Jung
Yun Seon Song
Kyunghoon Kim
Chang-Jin Lim
Eun-Hee Park
机构：
[1] Yonsei University College of Medicine,Brain Korea 21 Project for Medical Science, Department of Anatomy
[2] Sookmyung Women’s University,College of Pharmacy
[3] Kangwon National University,Division of Life Sciences and Research Institute of Life Sciences
[4] Kangwon National University,Division of Life Sciences, College of Natural Sciences
来源：
Archives of Pharmacal Research | 2010年 / 33卷
关键词：
Anti-angiogenic; Anti-inflammatory; Antinociceptive; Ethyl vanillin; Nitric oxide; Reactive oxygen species;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The present work aimed to assess novel pharmacological properties of ethyl vanillin (EVA) which is used as a flavoring agent for cakes, dessert, confectionary, etc. EVA exhibited an inhibitory activity in the chorioallantoic membrane angiogenesis. Anti-inflammatory activity of EVA was convinced using the two in vivo models, such as vascular permeability and air pouch models in mice. Antinociceptive activity of EVA was assessed using acetic acid-induced writhing model in mice. EVA suppressed production of nitric oxide and induction of inducible nitric oxide synthase in the lipopolysaccharide (LPS)-activated RAW264.7 macrophage cells. However, EVA could not suppress induction of cyclooxygenase-2 in the LPS-activated macrophages. EVA diminished reactive oxygen species level in the LPS-activated macrophages. EVA also suppressed enhanced matrix metalloproteinase-9 gelatinolytic activity in the LPSactivated RAW264.7 macrophage cells. EVA at the used concentrations couldn’t diminish viability of the macrophage cells. Taken together, the anti-angiogenic, anti-inflammatory and anti-nociceptive properties of EVA are based on its suppressive effect on the production of nitric oxide possibly via decreasing the reactive oxygen species level.
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页码：309 / 316
页数：7
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共 122 条
[1]  
Bubici C.(2006)Mutual cross-talk between reactive oxygen species and nuclear factor-kappa B: molecular basis and biological significance Oncogene 25 6731-6748
[2]  
Papa S.(2006)Role of nitric oxide and reactive oxygen species in arthritis Curr. Pharm. Des. 12 3551-3570
[3]  
Dean K.(2000)Cyclooxygenase-2-mediated angiogenesis in carrageenan-induced granulation tissue in rats J. Pharmacol. Exp. Ther. 295 802-809
[4]  
Franzoso G.(2000)Angiogenesis: potentials for pharmacologic intervention in the treatment of cancer, cardiovascular diseases, and chronic inflammation Pharmacol. Rev. 52 237-268
[5]  
Cuzzocrea S.(2000)Vanillin (3-methoxy-4-hydroxybenzaldehyde) inhibits mutation induced by hydrogen peroxide, N-methyl-N-nitrosoguanidine and mitomycin C but not 137Cs gamma radiation at the CD59 locus in human-hamster hybrid A(L) cells Mutagenesis 15 207-213
[6]  
Ghosh A. K.(1990)Synthetic analogues of fumagillin that inhibit angiogenesis and suppress tumour growth Nature 348 555-557
[7]  
Hirasawa N.(1998)Beta interferon inhibits HIV-1 Tat-induced angiogenesis: synergism with 13- Eur. J. Cancer 34 570-576
[8]  
Niki H.(2000) retinoic acid Mol. Cell. Biochem. 209 47-53
[9]  
Ohuchi K.(1994)Vanillin as an antioxidant in rat lever mitochondria: Inhibition of protein oxidation and lipid peroxidation induced by photosensitization Anal. Biochem. 218 325-329
[10]  
Griffioen A. W.(2004)Quantitative zymography: detection of picogram quantities of gelatinases J. Agric. Food Chem. 52 139-145
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