The role of calcium in endotoxin-induced release of calcitonin gene-related peptide (CGRP) from rat spinal cord

被引：0
作者：
Yueming Tang
Qide Han
Xian Wang
机构：
[1] Beijing Medical University,Institute of Vascular Medicine, The Third Hospital
来源：
Science in China Series C: Life Sciences | 1997年 / 40卷
关键词：
calcitonin gene-related peptide; endotoxin; calcium; rat spinal cord;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
In the present study, the role of calcium in endotoxin-induced CGRP release was studied. 2.5–50 CLg/mL endotoxin and 1–10 mmol/L caffeine caused concentration-dependent increase of CGRP release from rat spinal cordin vitro. However, no additive effect could be found when caffeine and endotoxin were concomitantly incubated. By using capsaicin, Ca2+-free medium, Omega-Conotoxin, nifedipine, W-7, ryanodine, MgCl2, Tris-ATP, ruthenium red, the results indicate that the release of CGRP evoked by endotoxin from the sensory fibers of rat spinal cord is dependent on extracellular calcium. After entering into the cell through the N-type calcium channel, calcium binds to calmodulin, and triggers calcium release from intracellular calcium store by activating the caffeine-sensitive but ryan-odine-insensitive mechanism.
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页码：437 / 442
页数：5
相关论文
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