Transcription factors and target genes of pre-TCR signaling

被引：0
作者：
Cristina López-Rodríguez
Jose Aramburu
Rosa Berga-Bolaños
机构：
[1] Universitat Pompeu Fabra,Immunology Unit, Department of Experimental and Health Sciences and Barcelona Biomedical Research Park
[2] National Institutes of Health,Immune Cells and Inflammation Section, National Institute on Aging
来源：
Cellular and Molecular Life Sciences | 2015年 / 72卷
关键词：
Thymocyte development; Pre-TCR expression; Pre-TCR signaling; Transcription factor; Gene expression; NF-κB; NFATc; NFAT5; ETS1; E2A/HEB proteins; Bcl2A1; p53; Intrinsic apoptotic pathway;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Almost 30 years ago pioneering work by the laboratories of Harald von Boehmer and Susumo Tonegawa provided the first indications that developing thymocytes could assemble a functional TCRβ chain-containing receptor complex, the pre-TCR, before TCRα expression. The discovery and study of the pre-TCR complex revealed paradigms of signaling pathways in control of cell survival and proliferation, and culminated in the recognition of the multifunctional nature of this receptor. As a receptor integrated in a dynamic developmental process, the pre-TCR must be viewed not only in the light of the biological outcomes it promotes, but also in context with those molecular processes that drive its expression in thymocytes. This review article focuses on transcription factors and target genes activated by the pre-TCR to drive its different outcomes.
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页码：2305 / 2321
页数：16
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