Synthesis and antiviral evaluation of 1,3-dimethyl-6-(1H-1,2,3-triazol-1-YL)pyrimidine-2,4(1H,3H)-dione derivatives

被引：0
作者：
A. Sh. El-Etrawy
A. A.-H. Abdel-Rahman
机构：
[1] Misr University for Science and Technology,Department of Organic Chemistry, College of Pharmacy
[2] Menoufia University,Department of Chemistry, Faculty of Science
来源：
Chemistry of Heterocyclic Compounds | 2010年 / 46卷
关键词：
pyrimidine derivatives; 1,2,3-triazoles; anti hepatitis A virus; cycloaddition;
D O I：
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学科分类号：
摘要：
Some 6-(1H-1,2,3-triazol-1-yl)pyrimidine-2,4(1H,3H)-dione derivatives were synthesized via the reaction of 6-azido-1,3-dimethyluracil with ethyl acetoacetate in the presence of sodium ethoxide. The antiviral activities of these compounds against Hepatitis A virus (HAV, MBB-cell culture adapted strain) and Herpes simples virus type-1 (HSV-1) were tested.
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页码：1105 / 1108
页数：3
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