Inhibition of ICAM2 induces radiosensitisation in oral squamous cell carcinoma cells

被引：0
作者：
T Ishigami
K Uzawa
K Fushimi
K Saito
Y Kato
D Nakashima
M Higo
Y Kouzu
H Bukawa
T Kawata
H Ito
H Tanzawa
机构：
[1] Graduate School of Medicine,Department of Clinical Molecular Biology
[2] Chiba University,Division of Dentistry and Oral
[3] 1-8-1 Inohana,Maxillofacial Surgery
[4] Chuo-ku,Department of Radiology
[5] Chiba University Hospital,undefined
[6] 1-8-1 Inohana,undefined
[7] Chuo-ku,undefined
[8] Graduate School of Medicine,undefined
[9] Chiba University,undefined
[10] 1-8-1 Inohana,undefined
[11] Chuo-ku,undefined
来源：
British Journal of Cancer | 2008年 / 98卷
关键词：
oral squamous cell carcinoma; radioresistance; ICAM2; siRNA;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
We recently identified genes and molecular pathways related to radioresistance of oral squamous cell carcinoma (OSCC) using Affymetrix GeneChip. The current study focused on the association between one of the target genes, intercellular adhesion molecule 2 (ICAM2), and resistance to X-ray irradiation in OSCC cells, and evaluated the antitumor efficacy of combining ICAM2 small interfering RNA (siRNA) and X-ray irradiation. Downregulation of ICAM2 expression by siRNA enhanced radiosensitivity of OSCC cells with the increased apoptotic phenotype via phosphorylation (ser473) of AKT and activation of caspase-3. Moreover, overexpression of ICAM2 induced greater OSCC cell resistance to the X-ray irradiation with the radioresistance phenotype. These results suggested that ICAM2 silencing is closely related to sensitivity of OSCC cells to radiotherapy, and that ICAM2 may be an effective radiotherapeutic target for this disease.
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页码：1357 / 1365
页数：8
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