RACK1, A multifaceted scaffolding protein: Structure and function

被引：0
作者：
David R Adams
Dorit Ron
Patrick A Kiely
机构：
[1] Heriot-Watt University,Department of Chemistry
[2] University of California,Ernest Gallo Research Center, Department of Neurology
[3] University of Limerick,Department of Life Sciences, and Materials and Surface Science Institute
来源：
Cell Communication and Signaling | / 9卷
关键词：
RACK1; WD-repeat; guanine nucleotide binding protein 2-like 1; (Gβ); heterotrimeric G-proteins; PKCβII; scaffolding protein;
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摘要：
The Receptor for Activated C Kinase 1 (RACK1) is a member of the tryptophan-aspartate repeat (WD-repeat) family of proteins and shares significant homology to the β subunit of G-proteins (Gβ). RACK1 adopts a seven-bladed β-propeller structure which facilitates protein binding. RACK1 has a significant role to play in shuttling proteins around the cell, anchoring proteins at particular locations and in stabilising protein activity. It interacts with the ribosomal machinery, with several cell surface receptors and with proteins in the nucleus. As a result, RACK1 is a key mediator of various pathways and contributes to numerous aspects of cellular function. Here, we discuss RACK1 gene and structure and its role in specific signaling pathways, and address how posttranslational modifications facilitate subcellular location and translocation of RACK1. This review condenses several recent studies suggesting a role for RACK1 in physiological processes such as development, cell migration, central nervous system (CN) function and circadian rhythm as well as reviewing the role of RACK1 in disease.
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  • [1] Li D(2001)WD-repeat proteins: structure characteristics, biological function, and their involvement in human diseases Cell Mol Life Sci 58 2085-2097
  • [2] Roberts R(1986)Repetitive segmental structure of the transducin beta subunit: homology with the CDC4 gene and identification of related mRNAs Proc Natl Acad Sci USA 83 2162-2166
  • [3] Fong HK(1994)The ancient regulatory-protein family of WD-repeat proteins Nature 371 297-300
  • [4] Hurley JB(2008)Diversity of WD-repeat proteins Subcell Biochem 48 20-30
  • [5] Hopkins RS(1999)The WD repeat: a common architecture for diverse functions Trends Biochem Sci 24 181-185
  • [6] Miake-Lye R(2011)Structure and function of WD40 domain proteins Protein Cell 2 202-214
  • [7] Johnson MS(1995)Heterotrimeric G proteins: organizers of transmembrane signals Cell 80 249-257
  • [8] Doolittle RF(2001)Protein folds propelled by diversity Prog Biophys Mol Biol 76 103-130
  • [9] Simon MI(1996)Crystal structure of a G-protein beta gamma dimer at 2.1A resolution Nature 379 369-374
  • [10] Neer EJ(1995)The structure of the G protein heterotrimer Gi alpha 1 beta 1 gamma 2 Cell 83 1047-1058
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