Synthesis of new phenylcarbamoylbenzoic acid derivatives and evaluation of their in vitro antioxidant activity

被引：0
作者：
Waleed A. Bayoumi
Magda A. Elsayed
机构：
[1] University of Mansoura,Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy
来源：
Medicinal Chemistry Research | 2012年 / 21卷
关键词：
Synthesis; Phenylcarbamoylbenzoic acid; Hydrazone; Acyl hydrazone; Phthaloyl derivatives; Antioxidant activity;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
In this study, new derivatives of phenylcarbamoylbenzoic acid were synthesized and evaluated for their in vitro antioxidant activity. The target compounds were prepared by bonding pharmacophoric moieties possessing antioxidant activity, including hydrazones, acid hydrazides, imino, Schiff’s bases, and phthalimides with phenylcarbamoylbenzoic acid via simple and efficient synthetic strategies. The structures of the newly synthesized compounds were confirmed by physical and spectral data. The in vitro antioxidant activity was carried out using ABTS antioxidant assay. All the tested compounds showed low antioxidant activity except compound 7, which showed moderate antioxidant activity compared with ascorbic acid.
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页码：1633 / 1640
页数：7
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