Zinc(II) complexes of carboxamide derivatives: Crystal structures and interaction with calf thymus DNA

被引:0
作者
BIPLAB MONDAL
BUDDHADEB SEN
ENNIO ZANGRANDO
PABITRA CHATTOPADHYAY
机构
[1] Burdwan University,Department of Chemistry
[2] Department of Chemical and Pharmaceutical Sciences,undefined
来源
Journal of Chemical Sciences | 2015年 / 127卷
关键词
Carboxamide derivative; zinc(II) complex; crystal structure; DNA binding;
D O I
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中图分类号
学科分类号
摘要
Two mononuclear zinc(II) complexes of newly designed carboxamide derivatives, formulated as [Zn(L1)3](ClO4)2 (1) and [Zn(L2)3](ClO4)2 (2) [where L1 = N-(furan-2-ylmethyl)-2-pyridinecarboxamide and L2 = N-(thiophen-2-ylmethyl)-2-pyridine-carboxamide], have been isolated in pure form in the reaction of perchlorate salts of Zn(II) with ligands L1 and L2, respectively. The two complexes were characterized by physicochemical and spectroscopic tools, and by X-ray crystal structures of both ligands and the complex 1. In complex 1, zinc(II) is chelated by three ligands with a distorted octahedral geometry. The DNA-binding properties of zinc complexes 1 and 2 have been investigated by spectroscopic methods and viscosity measurements. The results suggest that both complexes 1 and 2 bind to DNA in an intercalation mode between the uncoordinated furan or thiophene chromophore and the base pairs of DNA.
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页码:1747 / 1755
页数:8
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