Association of Bone Mineral Density with Polymorphism of the Human Calcium-Sensing Receptor Locus

被引：0

作者：

K. Tsukamoto

H. Orimo

T. Hosoi

M. Miyao

N. Ota

T. Nakajima

H. Yoshida

S. Watanabe

T. Suzuki

M. Emi

机构：

[1] Department of Molecular Biology,

[2] Institute of Gerontology,undefined

[3] Nippon Medical School,undefined

[4] 1-396 Kosugi-cho,undefined

[5] Nakahara-ku,undefined

[6] Kawasaki 211-8533,undefined

[7] Japan,undefined

[8] Department of Geriatrics,undefined

[9] Faculty of Medicine,undefined

[10] University of Tokyo,undefined

[11] Hongo,undefined

[12] Tokyo,undefined

[13] Japan,undefined

[14] Tokyo Metropolitan Institute of Gerontology and Hospital,undefined

[15] Itabashi-ku,undefined

[16] 173-0015,undefined

[17] Tokyo,undefined

[18] Japan,undefined

来源：

Calcified Tissue International | 2000年 / 66卷

关键词：

Bone Mineral Density; Bone Mass; Parathyroid Hormone; Parathyroid Gland; Calcium Homeostasis;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

A strong correlation between bone mass and genetic factors has been shown in twins and family studies. Some of the genes involved would regulate bone metabolism, bone formation, and resorption, all processes that determine bone mass. One candidate genes, calcium-sensing receptor (CASR) in the parathyroid gland, regulates calcium homeostasis by sensing decreases in extracellular calcium level and effecting an increase in secretion of parathyroid hormone (PTH) and calcium (Ca) reabsorption in the kidney. We have investigated a possible association between the CA-repeat polymorphism at the human CASR gene locus and the bone mineral density (BMD) of radial bone in 472 postmenopausal Japanese women. Genotypes were classified into nine groups according to the number of CA repeats present, from 20 to 12. BMD was expressed as the adjusted BMD, which was the body mass index (BMI), and age-adjusted average BMD. The 247 women who had an A3 allele (228 bp, containing 18 repeats of CA) had significantly lower adjusted BMD (mean ± SD: 0.303 ± 0.059 versus 0.316 ± 0.063 g/cm2; P= 0.0308) than the participants (n = 201) who did not carry an allele of that size. This result suggests that genetic variation at the CASR gene locus is associated with some determinants for BMD in postmenopausal women.

引用

页码：181 / 183

页数：2