Metformin activates AMP-activated protein kinase in primary human hepatocytes by decreasing cellular energy status

[1] Goodarzi MO(2005)Metformin revisited: re-evaluation of its properties and role in the pharmacopoeia of modern antidiabetic agents Diabetes Obes Metab 7 654-665

[2] Bryer-Ash M(2009)Medical management of hyperglycaemia in type 2 diabetes mellitus: a consensus algorithm for the initiation and adjustment of therapy: a consensus statement from the American Diabetes Association and the European Association for the Study of Diabetes Diabetologia 52 17-30

[3] Nathan DM(2006)Effects of metformin and thiazolidinediones on suppression of hepatic glucose production and stimulation of glucose uptake in type 2 diabetes: a systematic review Diabetologia 49 434-441

[4] Buse JB(1998)Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34). UK Prospective Diabetes Study (UKPDS) Group Lancet 352 854-865

[5] Davidson MB(2010)Metformin in cancer therapy: a new perspective for an old antidiabetic drug? Mol Cancer Ther 9 1092-1099

[6] Natali A(2001)Role of AMP-activated protein kinase in mechanism of metformin action J Clin Invest 108 1167-1174

[7] Ferrannini E(2005)The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin Science 310 1642-1646

[8] Ben Sahra I(2009)AMPK in health and disease Physiol Rev 89 1025-1078

[9] Le Marchand-Brustel Y(2007)AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy Nat Rev Mol Cell Biol 8 774-785

[10] Tanti JF(2011)AMPK is a direct adenylate charge-regulated protein kinase Science 332 1433-1435

[1] Goodarzi MO(2005)Metformin revisited: re-evaluation of its properties and role in the pharmacopoeia of modern antidiabetic agents Diabetes Obes Metab 7 654-665

[2] Bryer-Ash M(2009)Medical management of hyperglycaemia in type 2 diabetes mellitus: a consensus algorithm for the initiation and adjustment of therapy: a consensus statement from the American Diabetes Association and the European Association for the Study of Diabetes Diabetologia 52 17-30

[3] Nathan DM(2006)Effects of metformin and thiazolidinediones on suppression of hepatic glucose production and stimulation of glucose uptake in type 2 diabetes: a systematic review Diabetologia 49 434-441

[4] Buse JB(1998)Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34). UK Prospective Diabetes Study (UKPDS) Group Lancet 352 854-865

[5] Davidson MB(2010)Metformin in cancer therapy: a new perspective for an old antidiabetic drug? Mol Cancer Ther 9 1092-1099

[6] Natali A(2001)Role of AMP-activated protein kinase in mechanism of metformin action J Clin Invest 108 1167-1174

[7] Ferrannini E(2005)The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin Science 310 1642-1646

[8] Ben Sahra I(2009)AMPK in health and disease Physiol Rev 89 1025-1078

[9] Le Marchand-Brustel Y(2007)AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy Nat Rev Mol Cell Biol 8 774-785

[10] Tanti JF(2011)AMPK is a direct adenylate charge-regulated protein kinase Science 332 1433-1435