Effect of Nitric Oxide Donor, a Modulator of Tumor Drug Resistance, on Cell Death and p53 Protein Expression

被引：0
|
作者：
T. A. Rajewskaya
S. A. Goncharova
N. P. Konovalova
A. A. Terent’ev
M. A. Lapshina
机构：
[1] Russian Academy of Sciences,Institute for Problems of Chemical Physics
来源：
Bulletin of Experimental Biology and Medicine | 2009年 / 147卷
关键词：
drug resistance; NO donors; apoptosis; p53 protein expression;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Exogenous NO donor 3,3-bis-(nitroxymethyl)oxetane (NMO) was synthesized at the Institute for Problems of Chemical Physics (Russian Academy of Sciences). This compound was shown to inhibit cell death (apoptosis and necrosis) in cyclophosphamidesensitive and cyclophosphamide-resistant P388 murine tumor. p53 protein was expressed in both lines of tumor cells. NO donor NMO had little effect on p53 protein expression in cells of both stains. Our results suggest that the proapoptotic effect of NMO is mediated by the p53-independent molecular mechanisms.
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页码：421 / 423
页数：2
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