The role of milrinone in children with cardiovascular compromise: review of the literatureDie Rolle von Milrinon zur Behandlung des kardiovaskulären Versagens bei Kindern: eine Literaturübersicht

被引：0
作者：
Sascha Meyer
Ludwig Gortner
Kate Brown
Hashim Abdul-Khaliq
机构：
[1] University Hospital of Saarland,Department of Neonatal and Paediatric Intensive Care Medicine
[2] University College,Cardiac Intensive Care Unit, Great Ormond Street Hospital, London, and Institute of Child Health
[3] University Hospital of Saarland,Department of Pediatric Cardiology and Cardiac Intensive Care Medicine
来源：
Wiener Medizinische Wochenschrift | 2011年 / 161卷 / 7-8期
关键词：
Cardiopulmonary bypass surgery; Children; Low cardiac output syndrome; Milrinone; Phospho-diesterase inhibitor; Septic shock; Shock; Herz-Lungen-Maschine; Kinder; Low Cardiac Output-Syndrom; Milrinon; Phospho-Diesterase-Inhibitor; Septischer Schock; Schock;
D O I：
10.1007/s10354-011-0869-7
中图分类号：
学科分类号：
摘要：
BACKGROUND: Cardiovascular instability is a common complication in children after cardiac surgery and in various forms of shock. METHODS: Systematic literature review. RESULTS: Four randomized controlled trials (RCTs) were included in this systematic literature review. In children after corrective surgery for congenital heart disease milrinone significantly reduced the risk of development of LCOS compared with placebo. In another study in children with high pulmonary vascular resistance and impaired oxygenation after Fontan operation, inhalation of NO with milrinone led to the most significant reduction of pulmonary vascular resistance and improvement of oxygenation. When only milrinone was given these changes were less pronounced. In non-hyperdynamic septic shock, CI, SVI, and DO2 significantly increased while SVRI significantly decreased after milrinone when compared to placebo. CONCLUSIONS: There are a limited number of RCTs in children that suggest a beneficial effect of milrinone in the optimization of cardiovascular function after cardiac surgery and in septic shock.
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页码：184 / 191
页数：7
相关论文
共 58 条
[1]  
Brown KL(2003)Risk factors for long intensive care unit stay after cardiopulmonary bypass in children Crit Care Med 31 28-33
[2]  
Ridout DA(2004)A population pharmacokinetic analysis of milrinone in pediatric patients after cardiac surgery J Pharmacokinet Pharmacodyn 31 43-59
[3]  
Goldman AP(2009)Myocardial cell injury is common in children with septic shock Acta Paediatr 98 478-481
[4]  
Bailey JM(2001)Managing low cardiac output syndrome after congenital heart surgery Crit Care Med 29 S220-S230
[5]  
Hoffman TM(2006)Testing new drugs for heart failure in children Pediatr Crit Care Med 7 493-494
[6]  
Wessel DL(2003)Efficacy and safety of milrinone in preventing low cardiac output syndrome in infants and children after corrective surgery for congenital heart disease Circulation 107 996-1002
[7]  
Lodha A(2008)Nitric oxide and milrinone: combined effect on pulmonary circulation after Fontan-type procedure: a prospective, randomized study Ann Thorac Surg 86 882-888
[8]  
Arun S(1996)Hemodynamic effects of i.v. milrinone lactate in pediatric patients with septic shock. A prospective, double-blinded, randomized, placebo-controlled, interventional study Chest 109 1302-1312
[9]  
Vivekanandhan S(1998)Pharmacokinetics and pharmacodynamics of milrinone lactate in pediatric patients with septic shock J Pediatr 132 329-334
[10]  
Wessel DL(1995)Milrinone: systemic and pulmonary hemodynamic effects in neonates after cardiac surgery Crit Care Med 23 1907-1914
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