Proceedings of the First Curing Coma Campaign NIH Symposium: Challenging the Future of Research for Coma and Disorders of Consciousness

被引:0
作者
Jan Claassen
Yama Akbari
Sheila Alexander
Mary Kay Bader
Kathleen Bell
Thomas P. Bleck
Melanie Boly
Jeremy Brown
Sherry H.-Y. Chou
Michael N. Diringer
Brian L. Edlow
Brandon Foreman
Joseph T. Giacino
Olivia Gosseries
Theresa Green
David M. Greer
Daniel F. Hanley
Jed A. Hartings
Raimund Helbok
J. Claude Hemphill
H. E. Hinson
Karen Hirsch
Theresa Human
Michael L. James
Nerissa Ko
Daniel Kondziella
Sarah Livesay
Lori K. Madden
Shraddha Mainali
Stephan A. Mayer
Victoria McCredie
Molly M. McNett
Geert Meyfroidt
Martin M. Monti
Susanne Muehlschlegel
Santosh Murthy
Paul Nyquist
DaiWai M. Olson
J. Javier Provencio
Eric Rosenthal
Gisele Sampaio Silva
Simone Sarasso
Nicholas D. Schiff
Tarek Sharshar
Lori Shutter
Robert D. Stevens
Paul Vespa
Walter Videtta
Amy Wagner
Wendy Ziai
机构
[1] Columbia University and New York-Presbyterian Hospital,Department of Neurology
[2] University of California,Departments of Neurology, Neurological Surgery, and Anatomy & Neurobiology and Beckman Laser Institute and Medical Clinic
[3] Irvine,Acute and Tertiary Care, School of Nursing and Critical Care Medicine, School of Medicine
[4] University of Pittsburgh,Department of Physical Medicine and Rehabilitation
[5] Mission Hospital,Davee Department of Neurology, Feinberg School of Medicine
[6] University of Texas Southwestern Medical Center,Department of Neurology, School of Medicine and Public Health
[7] Northwestern University,Office of Emergency Care Research, Division of Clinical Research
[8] University of Wisconsin–Madison,Departments of Critical Care Medicine, Neurology, and Neurosurgery, School of Medicine
[9] National Institute of Neurological Disorders and Stroke,Department of Neurology
[10] University of Pittsburgh,Department of Neurology, Center for Neurotechnology and Neurorecovery, Massachusetts General Hospital and Harvard Medical School
[11] Washington University in St. Louis,Departments of Neurology and Rehabilitation Medicine, College of Medicine
[12] Harvard University,Department of Physical Medicine and Rehabilitation, Harvard Medical School
[13] University of Cincinnati,GIGA Consciousness After Coma Science Group
[14] Harvard University,School of Nursing
[15] University of Liege,Department of Neurology, School of Medicine
[16] Queensland University of Technology,Division of Brain Injury Outcomes, Department of Neurology, School of Medicine
[17] Boston University,Department of Neurosurgery, College of Medicine
[18] Johns Hopkins University,Neurocritical Care Unit, Department of Neurology
[19] University of Cincinnati,Department of Neurology, Weill Institute for Neurosciences, School of Medicine
[20] Medical University of Innsbruck,Department of Neurology, School of Medicine
[21] University of California,Department of Neurology
[22] San Francisco,Department of Pharmacy
[23] Oregon Health & Science University,Departments of Anesthesiology and Neurology
[24] Stanford University,Department of Clinical Medicine
[25] Barnes Jewish Hospital,Department of Neurology, Rigshospitalet
[26] Duke University,College of Nursing
[27] University of Copenhagen,Center for Nursing Science
[28] Copenhagen University Hospital,Department of Neurology
[29] Rush University,Department of Neurology
[30] University of California,Interdepartmental Division of Critical Care, Department of Respirology
[31] Davis,College of Nursing
[32] The Ohio State University,Department of Intensive Care Medicine
[33] New York Medical College,Departments of Neurosurgery and Psychology, Brain Injury Research Center
[34] University of Toronto,Departments of Neurology, Anesthesiology/Critical Care, and Surgery, Medical School
[35] The Ohio State University,Department of Neurology
[36] University Hospitals Leuven and University of Leuven,Division of Neurosciences Critical Care, Departments of Anesthesiology and Critical Care Medicine, Neurology, and Neurosurgery, School of Medicine
[37] University of California,Departments of Neurology and Neurosurgery
[38] Los Angeles,Departments of Neurology and Neuroscience, School of Medicine
[39] University of Massachusetts,Department of Neurology, Harvard Medical School
[40] Weill Cornell Medical College,Department of Neurology
[41] Johns Hopkins University,Department of Biomedical and Clinical Sciences “L. Sacco”
[42] University of Texas Southwestern Medical Center,Department of Neurology and Brain Mind Research Institute, Weill Cornell Medicine
[43] University of Virginia,Department of Intensive Care
[44] Harvard University,Departments of Neurosurgery and Neurology
[45] Albert Einstein Israelite Hospital and Universidade Federal de São Paulo,Department of Physical Medicine and Rehabilitation, School of Medicine
[46] Università degli Studi di Milano,Division of Neurosciences Critical Care, Department of Neurology, School of Medicine
[47] Cornell University,undefined
[48] Paris Descartes University,undefined
[49] University of California,undefined
[50] Los Angeles,undefined
来源
Neurocritical Care | 2021年 / 35卷
关键词
Coma; Consciousness; Electrophysiology; Magnetic resonance imaging; Biomarkers;
D O I
暂无
中图分类号
学科分类号
摘要
Coma and disorders of consciousness (DoC) are highly prevalent and constitute a burden for patients, families, and society worldwide. As part of the Curing Coma Campaign, the Neurocritical Care Society partnered with the National Institutes of Health to organize a symposium bringing together experts from all over the world to develop research targets for DoC. The conference was structured along six domains: (1) defining endotype/phenotypes, (2) biomarkers, (3) proof-of-concept clinical trials, (4) neuroprognostication, (5) long-term recovery, and (6) large datasets. This proceedings paper presents actionable research targets based on the presentations and discussions that occurred at the conference. We summarize the background, main research gaps, overall goals, the panel discussion of the approach, limitations and challenges, and deliverables that were identified.
引用
收藏
页码:4 / 23
页数:19
相关论文
共 537 条
[1]  
Provencio JJ(2020)The Curing Coma Campaign: framing initial scientific challenges—proceedings of the first Curing Coma Campaign Scientific Advisory Council Meeting Neurocrit Care 33 1-12
[2]  
Hemphill JC(2014)End-of-life decisions in patients with severe acute brain injury Lancet Neurol 13 515-524
[3]  
Claassen J(2020)Why most acute stroke studies are positive in animals but not in patients: a systematic comparison of preclinical, early phase, and phase 3 clinical trials of neuroprotective agents Ann Neurol 87 40-51
[4]  
Geurts M(2015)Traumatic brain injury in 2014: progress, failures and new approaches for TBI research Nat Rev Neurol 11 71-72
[5]  
Macleod MR(2015)Bench-to-bedside and bedside back to the bench; seeking a better understanding of the acute pathophysiological process in severe traumatic brain injury Front Neurol 6 47-2730
[6]  
van Thiel GJMW(2017)The Traumatic Brain Injury Endpoints Development (TED) Initiative: progress on a public–private regulatory collaboration to accelerate diagnosis and treatment of traumatic brain injury J Neurotrauma 34 2721-589
[7]  
van Gijn J(2010)Willful modulation of brain activity in disorders of consciousness N Engl J Med 362 579-2414
[8]  
Kappelle LJ(2006)Detecting awareness in the vegetative state Science 313 1402-2505
[9]  
van der Worp HB(2017)Early detection of consciousness in patients with acute severe traumatic brain injury Brain 140 2399-125
[10]  
Schmidt-Pogoda A(2019)Detection of brain activation in unresponsive patients with acute brain injury N Engl J Med 380 2497-370