Therapeutic Applications for Adipose-Derived Stem Cells in Wound Healing and Tissue Engineering

被引：13
作者：
McCarthy M.E. [1 ]
Brown T.A. [1 ]
Bukowska J. [1 ,2 ]
Bunnell B.A. [1 ,3 ,4 ]
Frazier T. [5 ,8 ]
Wu X. [8 ]
Gimble J.M. [1 ,5 ,6 ,7 ,8 ]
机构：
[1] Center for Stem Cell Research and Regenerative Medicine, Tulane University, New Orleans, LA
[2] Polish Academy of Science, Olsztyn
[3] Department of Pharmacology, Tulane University, New Orleans, LA
[4] Tulane National Primate Research Center, Tulane University, New Orleans, LA
[5] Department of Structural and Cell Biology, Tulane University, New Orleans, LA
[6] Department of Medicine, Tulane University, New Orleans, LA
[7] Department of Surgery, Tulane University, New Orleans, LA
[8] LaCell LLC and Obatala Sciences Inc, New Orleans, LA
来源：
Current Stem Cell Reports | 2018年 / 4卷 / 2期
关键词：
Adipose-derived stem cells; Cytokine; Pressure ulcers; Scaffold; Skin wound healing; Stromal vascular fraction;
D O I：
10.1007/s40778-018-0125-9
中图分类号：
学科分类号：
摘要：
Purpose of Review: The use of adipose-derived stem cells (ASCs) has garnered recent interest for their accessibility and potential utility in wound healing applications. The purpose of this review is to provide an overview of developments within the last 5 years regarding therapeutic use of ASCs in wound healing applications. Recent Findings: Recent studies have demonstrated that ASCs do not exert the majority of their effects through differentiation, as previously believed. Rather, when they improve healing, it is via secreted factors that promote vascularization and control inflammation. New therapeutic approaches reflect this shift in belief. Summary: ASC-based therapies can improve outcomes in the treatment of a variety of wound types. Questions about how to best implement ASCs in the clinical setting remain, and their answers will profoundly influence the utility and availability of ASC-based therapies. © 2018, Springer International Publishing AG, part of Springer Nature.
引用
收藏
页码：127 / 137
页数：10
相关论文
共 97 条
[91]  
Duscher D., Rennert R.C., Januszyk M., Et al., Aging disrupts cell subpopulation dynamics and diminishes the function of mesenchymal stem cells, Sci Rep, 4, (2014)
[92]  
Cronk S.M., Kelly-Goss M.R., Ray H.C., Mendel T.A., Hoehn K.L., Bruce A.C., Dey B.K., Guendel A.M., Tavakol D.N., Herman I.M., Peirce S.M., Yates P.A., Adipose-derived stem cells from diabetic mice show impaired vascular stabilization in a murine model of diabetic retinopathy, Stem Cells Transl Med, 4, pp. 459-467, (2015)
[93]  
Chiu Y.-J., Yang J.-S., Hsu H.-S., Tsai C.-H., Ma H., Adipose-derived stem cell conditioned medium attenuates cisplatin-triggered apoptosis in tongue squamous cell carcinoma, Oncol Rep, 39, pp. 651-658, (2018)
[94]  
Harris W.M., Zhang P., Plastini M., Ortiz T., Kappy N., Benites J., Alexeev E., Chang S., Brockunier R., Carpenter J.P., Brown S.A., Evaluation of function and recovery of adipose-derived stem cells after exposure to paclitaxel, Cytotherapy, 19, pp. 211-221, (2017)
[95]  
Gong J.H., Dong J.Y., Xie T., Lu S.L., The influence of AGEs environment on proliferation, apoptosis, homeostasis, and endothelial cell differentiation of human adipose stem cells, Int J Low Extrem Wounds, 16, pp. 94-103, (2017)
[96]  
Lopez M.J., McIntosh K.R., Spencer N.D., Borneman J.N., Horswell R., Anderson P., Yu G., Gaschen L., Gimble J.M., Acceleration of spinal fusion using syngeneic and allogeneic adult adipose derived stem cells in a rat model, J Orthop Res, 27, pp. 366-373, (2009)
[97]  
McIntosh K.R., Lopez M.J., Borneman J.N., Spencer N.D., Anderson P.A., Gimble J.M., Immunogenicity of allogeneic adipose-derived stem cells in a rat spinal fusion model, Tissue Eng Part A, 15, pp. 2677-2686, (2009)
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