Therapeutic Applications for Adipose-Derived Stem Cells in Wound Healing and Tissue Engineering

被引：13
作者：
McCarthy M.E. [1 ]
Brown T.A. [1 ]
Bukowska J. [1 ,2 ]
Bunnell B.A. [1 ,3 ,4 ]
Frazier T. [5 ,8 ]
Wu X. [8 ]
Gimble J.M. [1 ,5 ,6 ,7 ,8 ]
机构：
[1] Center for Stem Cell Research and Regenerative Medicine, Tulane University, New Orleans, LA
[2] Polish Academy of Science, Olsztyn
[3] Department of Pharmacology, Tulane University, New Orleans, LA
[4] Tulane National Primate Research Center, Tulane University, New Orleans, LA
[5] Department of Structural and Cell Biology, Tulane University, New Orleans, LA
[6] Department of Medicine, Tulane University, New Orleans, LA
[7] Department of Surgery, Tulane University, New Orleans, LA
[8] LaCell LLC and Obatala Sciences Inc, New Orleans, LA
来源：
Current Stem Cell Reports | 2018年 / 4卷 / 2期
关键词：
Adipose-derived stem cells; Cytokine; Pressure ulcers; Scaffold; Skin wound healing; Stromal vascular fraction;
D O I：
10.1007/s40778-018-0125-9
中图分类号：
学科分类号：
摘要：
Purpose of Review: The use of adipose-derived stem cells (ASCs) has garnered recent interest for their accessibility and potential utility in wound healing applications. The purpose of this review is to provide an overview of developments within the last 5 years regarding therapeutic use of ASCs in wound healing applications. Recent Findings: Recent studies have demonstrated that ASCs do not exert the majority of their effects through differentiation, as previously believed. Rather, when they improve healing, it is via secreted factors that promote vascularization and control inflammation. New therapeutic approaches reflect this shift in belief. Summary: ASC-based therapies can improve outcomes in the treatment of a variety of wound types. Questions about how to best implement ASCs in the clinical setting remain, and their answers will profoundly influence the utility and availability of ASC-based therapies. © 2018, Springer International Publishing AG, part of Springer Nature.
引用
收藏
页码：127 / 137
页数：10
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