Inflammation and Stroke: An Overview

被引：0
作者：
Josef Anrather
Costantino Iadecola
机构：
[1] Weill Cornell Medicine,Feil Family Brain and Mind Research Institute
来源：
Neurotherapeutics | 2016年 / 13卷
关键词：
Stroke; ischemia; inflammation; immune response; immunomodulation;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The immune response to acute cerebral ischemia is a major factor in stroke pathobiology and outcome. While the immune response starts locally in occluded and hypoperfused vessels and the ischemic brain parenchyma, inflammatory mediators generated in situ propagate through the organism as a whole. This “spillover” leads to a systemic inflammatory response first, followed by immunosuppression aimed at dampening the potentially harmful proinflammatory milieu. In this overview we will outline the inflammatory cascade from its starting point in the vasculature of the ischemic brain to the systemic immune response elicited by brain ischemia. Potential immunomodulatory therapeutic approaches, including preconditioning and immune cell therapy will also be discussed.
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页码：661 / 670
页数：9
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