Xenotransplantation becoming reality

被引:0
作者
Konrad Fischer
Angelika Schnieke
机构
[1] Technical University of Munich,Chair of Livestock Biotechnology, School of Life Sciences
来源
Transgenic Research | 2022年 / 31卷
关键词
Xenotransplantation; Organ transplantation; Pigs; Swine; Genetic engineering; Genome editing; Clinical; Bennett Senior;
D O I
暂无
中图分类号
学科分类号
摘要
To bridge the gap between organ demand and supply, xenotransplantation has long been considered as a realistic option for end-stage organ failure. Early this year this promise became reality for David Bennett Sr., the first patient whose own failing heart was replaced with a xeno-pig heart. To get here has been a rollercoaster ride of physiological hurdles seemingly impossible to overcome, technological breakthroughs and ethical and safety concerns. It started in 1984, with Stephanie Fae Beauclair, also known as baby Fae, receiving a baboon heart, which allowed her to survive for another 30 days. For ethical reasons primate work was soon abandoned in favour of the pig. But increased phylogenetic distance also brought with it an increased immunological incompatibility. It has been the development of ever more sophisticated genetic engineering tools, which brought down the physiological barriers, enabled humanisation of porcine organs and helped addressing safety concerns. This renewed the confidence in xenotransplantation, brought new funding opportunities and resulted finally in the first in human trial.
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页码:391 / 398
页数:7
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