Autoimmune Lymphoproliferative Syndrome: Response to Mycophenolate Mofetil and Pyrimethamine/Sulfadoxine in a 5-Year-Old Child

被引：0
作者：
Sunaina Arora
Neeraj Singh
Gurmeet Kaur Chaudhary
M. Joseph John
机构：
[1] Christian Medical College,Department of Pediatrics
[2] Christian Medical College,Department of Clinical Hematology and Hemato
来源：
Indian Journal of Hematology and Blood Transfusion | 2011年 / 27卷
关键词：
Autoimmune lymphoproliferative syndrome; Mycophenolate-Mofetil; Pyrimethamine/Sulfadoxine;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Autoimmune Lymphoproliferative Syndrome (ALPS) is a rare inherited disorder of disrupted lymphocyte homeostasis characterized by chronic splenomegaly and lymphadenopathy of early onset, hypergammaglobulinemia (Ig G and Ig A), autoimmune phenomena, and expanded populations of TCR-α/β+, CD3+, CD4-, CD8-T cells (Fisher et al. Cell 81:935–946; 1995), called double negative T-cells [(DN) T cells]. We discuss a case of ALPS which showed good response to immunosuppressant drug Mycophenolate-Mofetil in combination with Pyrimethamine/Sulfadoxine.
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页码：101 / 103
页数：2
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